Sinonasal Metastasis: A Clinicopathological Series of Seven Cases
Introduction: Metastases to the sinonasal region is rare and presents with features overlapping with various regional neoplastic/non-neoplastic lesions. This series aims to highlight the clinical presentations and diagnostic difficulties of sinonasal metastases. Material and Method: A review of pert...
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Light House Polyclinic Mangalore
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doaj-e0a6b961710a4e018e971ba7804443542020-11-25T03:44:39ZengLight House Polyclinic Mangalore Online Journal of Health & Allied Sciences0972-59970972-59972020-09-01192Sinonasal Metastasis: A Clinicopathological Series of Seven CasesVarun Kumar Singh0Mary Mathew1Ranjini Kudva2Kanthilatha Pai3Arijit Bishnu4Assistant Professor, Pathology, Melaka Manipal Medical College, Manipal campus, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaProfessor, Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaProfessor, Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaProfessor, Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaRegistrar, Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, IndiaIntroduction: Metastases to the sinonasal region is rare and presents with features overlapping with various regional neoplastic/non-neoplastic lesions. This series aims to highlight the clinical presentations and diagnostic difficulties of sinonasal metastases. Material and Method: A review of pertinent demographic and laboratory data for patients diagnosed with metastases to the sinonasal region, over a period of 6 years (2012- 2017) was done. Results and Discussion: Seven cases (males- 6, females-1) of sinonasal metastases were identified. The age ranged from 41-72 years. The common clinical presentation was nasal obstruction, epistaxis, and pain. Grossly tumors were irregular masses (mean size – 4.1cm) with maxillary sinus as the most common site. The histologic types included Squamous cell carcinoma (3 cases), clear cell renal cell carcinoma (2 cases), and one case each of infiltrating ductal carcinoma, and eccrine spiradenocarcinoma. The site of the primary tumor was larynx (2/7), kidney (2/7), breast (1/7), lung (1/7), and neck (1/7). The mean time interval between the primary tumor and metastasis was 4.5 months. All cases were managed with resection of the metastatic tumor. Metastatic breast and renal tumors comprise the bulk of reported cases in English literature. Metastasis from a lung carcinoma are rare and here we report the first case of an eccrine spiradenocarcinoma to maxillary sinus. Conclusions: Owing to the overlapping clinical presentations, a high degree of suspicion is needed in patients with previous history of malignancy for early diagnosis. The current course of therapy is palliative for such patients and carries a grim prognosis.https://www.ojhas.org/issue74/2020-2-12.htmlmetastasisnasal obstructionrenal cell carcinomalung carcinomaeccrine spiradenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Varun Kumar Singh Mary Mathew Ranjini Kudva Kanthilatha Pai Arijit Bishnu |
spellingShingle |
Varun Kumar Singh Mary Mathew Ranjini Kudva Kanthilatha Pai Arijit Bishnu Sinonasal Metastasis: A Clinicopathological Series of Seven Cases Online Journal of Health & Allied Sciences metastasis nasal obstruction renal cell carcinoma lung carcinoma eccrine spiradenocarcinoma |
author_facet |
Varun Kumar Singh Mary Mathew Ranjini Kudva Kanthilatha Pai Arijit Bishnu |
author_sort |
Varun Kumar Singh |
title |
Sinonasal Metastasis: A Clinicopathological Series of Seven Cases |
title_short |
Sinonasal Metastasis: A Clinicopathological Series of Seven Cases |
title_full |
Sinonasal Metastasis: A Clinicopathological Series of Seven Cases |
title_fullStr |
Sinonasal Metastasis: A Clinicopathological Series of Seven Cases |
title_full_unstemmed |
Sinonasal Metastasis: A Clinicopathological Series of Seven Cases |
title_sort |
sinonasal metastasis: a clinicopathological series of seven cases |
publisher |
Light House Polyclinic Mangalore |
series |
Online Journal of Health & Allied Sciences |
issn |
0972-5997 0972-5997 |
publishDate |
2020-09-01 |
description |
Introduction: Metastases to the sinonasal region is rare and presents with features overlapping with various regional neoplastic/non-neoplastic lesions. This series aims to highlight the clinical presentations and diagnostic difficulties of sinonasal metastases. Material and Method: A review of pertinent demographic and laboratory data for patients diagnosed with metastases to the sinonasal region, over a period of 6 years (2012- 2017) was done. Results and Discussion: Seven cases (males- 6, females-1) of sinonasal metastases were identified. The age ranged from 41-72 years. The common clinical presentation was nasal obstruction, epistaxis, and pain. Grossly tumors were irregular masses (mean size – 4.1cm) with maxillary sinus as the most common site. The histologic types included Squamous cell carcinoma (3 cases), clear cell renal cell carcinoma (2 cases), and one case each of infiltrating ductal carcinoma, and eccrine spiradenocarcinoma. The site of the primary tumor was larynx (2/7), kidney (2/7), breast (1/7), lung (1/7), and neck (1/7). The mean time interval between the primary tumor and metastasis was 4.5 months. All cases were managed with resection of the metastatic tumor. Metastatic breast and renal tumors comprise the bulk of reported cases in English literature. Metastasis from a lung carcinoma are rare and here we report the first case of an eccrine spiradenocarcinoma to maxillary sinus. Conclusions: Owing to the overlapping clinical presentations, a high degree of suspicion is needed in patients with previous history of malignancy for early diagnosis. The current course of therapy is palliative for such patients and carries a grim prognosis. |
topic |
metastasis nasal obstruction renal cell carcinoma lung carcinoma eccrine spiradenocarcinoma |
url |
https://www.ojhas.org/issue74/2020-2-12.html |
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