Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer

Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer

Background Durable efficacy of immune checkpoint blockade (ICB) occurred in a small number of patients with metastatic gastric cancer (mGC) and the determinant biomarker of response to ICB remains unclear.Methods We developed an open-source TMEscore R package, to quantify the tumor microenvironment...

Full description

Bibliographic Details
Main Authors:	Min Shi, Yong Li, Jianhua Wu, Huiying Sun, Jianjun Peng, Kyoung-Mee Kim, Jian Xiao, Huiyan Luo, Jiani Wu, Yulin Liao, Li Sun, Na Huang, Gaofeng Wang, Rui Zhou, Dongqiang Zeng, Zilan Ye, Yunfang Yu, Xiaoxiang Rong, Wenjun Qiu, Yichen Xue, Jianping Bin, Nailin Li, Wangjun Liao
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2021-08-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/9/8/e002467.full

Similar Items

Immunosuppressive Microenvironment Revealed by Immune Cell Landscape in Pre-metastatic Liver of Colorectal Cancer
by: Dongqiang Zeng, et al.
Published: (2021-03-01)

A robust panel based on tumour microenvironment genes for prognostic prediction and tailoring therapies in stage I–III colon cancerResearch in context
by: Rui Zhou, et al.
Published: (2019-04-01)

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures
by: Dongqiang Zeng, et al.
Published: (2021-07-01)

Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response
by: Jiani Wu, et al.
Published: (2021-09-01)

Comprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancer
by: Yisheng Fang, et al.
Published: (2021-01-01)

Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors
by: Zihui Li, et al.
Published: (2020-11-01)

The regulation of immune checkpoints by the hypoxic tumor microenvironment
by: Min Hu, et al.
Published: (2021-05-01)

Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis
by: Jingwen Zhang, et al.
Published: (2016-01-01)

Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis
by: Zhenzhen Wu, et al.
Published: (2015-01-01)

Identification of the Prognosis Value and Potential Mechanism of Immune Checkpoints in Renal Clear Cell Carcinoma Microenvironment
by: Guodong Liao, et al.
Published: (2021-07-01)

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
by: Min Yang, et al.
Published: (2020-01-01)

Immune Checkpoint Inhibitors in Human Glioma Microenvironment
by: Amina Ghouzlani, et al.
Published: (2021-07-01)

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy
by: Rachael M. Zemek, et al.
Published: (2020-02-01)

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies
by: Florent Petitprez, et al.
Published: (2020-05-01)

A metabolic immune checkpoint: adenosine in tumor microenvironment
by: Akio eOhta
Published: (2016-03-01)

The Impact of NOTCH Pathway Alteration on Tumor Microenvironment and Clinical Survival of Immune Checkpoint Inhibitors in NSCLC
by: Xiaohua Li, et al.
Published: (2021-07-01)

Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades
by: Jun-Yan Li, et al.
Published: (2021-02-01)

Optimizing Checkpoint Restart with Data Deduplication
by: Zhengyu Chen, et al.
Published: (2016-01-01)

Joint association of patients’ sex and PD‐L1 expression with overall survival benefits and tumor‐immune microenvironment in immune checkpoint inhibitors for cancers
by: Anlin Li, et al.
Published: (2020-06-01)

Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition
by: Jared M. Newton, et al.
Published: (2019-08-01)

Checkpoint blockade‐based immunotherapy in the context of tumor microenvironment: Opportunities and challenges
by: Jingjing Duan, et al.
Published: (2018-09-01)

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
by: Nicole E. Scharping, et al.
Published: (2016-12-01)

The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy
by: Bonnie L. Russell, et al.
Published: (2021-06-01)

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
by: Chia-Sing Lu, et al.
Published: (2020-07-01)

Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors
by: Xiaoying Li, et al.
Published: (2021-10-01)

Viral status, immune microenvironment and immunological response to checkpoint inhibitors in hepatocellular carcinoma
by: Su Jin Lim, et al.
Published: (2020-06-01)

N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells
by: Jun Jing, et al.
Published: (2021-03-01)

Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function
by: Hye Ryun Kim, et al.
Published: (2019-12-01)

Local Targeting of NAD + Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma
by: Li, Ming, et al.
Published: (2022)

New Insights into the Role of Autophagy in Tumor Immune Microenvironment
by: Chia-Jung Li, et al.
Published: (2017-07-01)

Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer
by: Zhenhua Huang, et al.
Published: (2018-05-01)

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
by: Tianyu Tang, et al.
Published: (2021-02-01)

Transforming of the Tumor Microenvironment: Implications for TGF-β Inhibition in the Context of Immune-Checkpoint Therapy
by: Stefanie Löffek
Published: (2018-01-01)

Analysis of Tumor Microenvironment Characteristics in Bladder Cancer: Implications for Immune Checkpoint Inhibitor Therapy
by: Xingyu Chen, et al.
Published: (2021-04-01)

Potential Prognostic Value and Mechanism of Stromal-Immune Signature in Tumor Microenvironment for Stomach Adenocarcinoma
by: Xinying Zhu, et al.
Published: (2020-01-01)

Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma
by: Fan Xing, et al.
Published: (2021-07-01)

Tumor Immune Microenvironment Components and Checkpoint Molecules in Anaplastic Variant of Diffuse Large B-Cell Lymphoma
by: Tianqi Xu, et al.
Published: (2021-06-01)

Role of the complement system in the tumor microenvironment
by: Ronghua Zhang, et al.
Published: (2019-11-01)

9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy
by: Guangchun Han, et al.
Published: (2021-09-01)

An immunomodulatory signature of responsiveness to immune checkpoint blockade therapy
by: Hongru Shen, et al.
Published: (2020-12-01)