Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps
Proton pump inhibitors (PPIs) are the most potent anti-acid agents and are extensively used worldwide. PPI-induced hypergastrinemia is one of the very few side effects associated with these drugs. However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpo...
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doaj-e0a951ca697c497c9c6c23dda8686c702020-11-25T02:11:58ZengWileyKaohsiung Journal of Medical Sciences1607-551X2010-02-01262768310.1016/S1607-551X(10)70011-5Influence of Proton Pump Inhibitor Use in Gastrointestinal PolypsWen-Hung Hsu0I-Chen Wu1Chao-Hung Kuo2Yu-Chung Su3Chien-Yu Lu4Fu-Chen Kuo5Chang-Ming Jan6Wen-Ming Wang7Deng-Chyang Wu8Fang-Jung Yu9Division of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Gynecology and Obstetrics, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanProton pump inhibitors (PPIs) are the most potent anti-acid agents and are extensively used worldwide. PPI-induced hypergastrinemia is one of the very few side effects associated with these drugs. However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpose of this study was to analyze the relationship between the occurrence of gastrointestinal polyps and hypergastrinemia induced by PPIs. This study included 259 patients who underwent colonoscopy and esophagogastroduodenoscopy between January and August 2007. Chart records, including medication history and fasting plasma gastrin level, were reviewed and analyzed. Any subtle polypoid lesions in the stomach and colon were sampled by biopsy for histological examination. Helicobacter pylori infection status was examined by a rapid urea test during esophagogastroduodenoscopy. All patients underwent endoscopy examinations. A total of 122 patients were receiving PPI treatment for either peptic ulcer disease or reflux esophagitis and were included as the study group. The remaining 137 patients were not treated with PPIs and served as the non-PPI group. The mean fasting gastrin level in PPI users versus non-PPI users was 121.8 ng/L versus 56.8 ng/L, respectively (p < 0.001). Although the prevalence of gastric gland polyps was higher in the PPI group (65.6% vs. 37.2%, p < 0.001), there was no difference in the prevalence of colonic adenomatous polyps observed (22.13% vs. 22.62%, p = 0.928). In conclusion, the prevalence of gastric polyps, particularly fundic gland polyps, was higher among PPI users. However, the prevalence of colonic polyps was not affected by PPI use, regardless of past history of colonic adenomatous polyps.http://www.sciencedirect.com/science/article/pii/S1607551X10700115colon polypsgastric polypsgastrinproton pump inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen-Hung Hsu I-Chen Wu Chao-Hung Kuo Yu-Chung Su Chien-Yu Lu Fu-Chen Kuo Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Fang-Jung Yu |
spellingShingle |
Wen-Hung Hsu I-Chen Wu Chao-Hung Kuo Yu-Chung Su Chien-Yu Lu Fu-Chen Kuo Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Fang-Jung Yu Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps Kaohsiung Journal of Medical Sciences colon polyps gastric polyps gastrin proton pump inhibitor |
author_facet |
Wen-Hung Hsu I-Chen Wu Chao-Hung Kuo Yu-Chung Su Chien-Yu Lu Fu-Chen Kuo Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Fang-Jung Yu |
author_sort |
Wen-Hung Hsu |
title |
Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps |
title_short |
Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps |
title_full |
Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps |
title_fullStr |
Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps |
title_full_unstemmed |
Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps |
title_sort |
influence of proton pump inhibitor use in gastrointestinal polyps |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2010-02-01 |
description |
Proton pump inhibitors (PPIs) are the most potent anti-acid agents and are extensively used worldwide. PPI-induced hypergastrinemia is one of the very few side effects associated with these drugs. However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpose of this study was to analyze the relationship between the occurrence of gastrointestinal polyps and hypergastrinemia induced by PPIs. This study included 259 patients who underwent colonoscopy and esophagogastroduodenoscopy between January and August 2007. Chart records, including medication history and fasting plasma gastrin level, were reviewed and analyzed. Any subtle polypoid lesions in the stomach and colon were sampled by biopsy for histological examination. Helicobacter pylori infection status was examined by a rapid urea test during esophagogastroduodenoscopy. All patients underwent endoscopy examinations. A total of 122 patients were receiving PPI treatment for either peptic ulcer disease or reflux esophagitis and were included as the study group. The remaining 137 patients were not treated with PPIs and served as the non-PPI group. The mean fasting gastrin level in PPI users versus non-PPI users was 121.8 ng/L versus 56.8 ng/L, respectively (p < 0.001). Although the prevalence of gastric gland polyps was higher in the PPI group (65.6% vs. 37.2%, p < 0.001), there was no difference in the prevalence of colonic adenomatous polyps observed (22.13% vs. 22.62%, p = 0.928). In conclusion, the prevalence of gastric polyps, particularly fundic gland polyps, was higher among PPI users. However, the prevalence of colonic polyps was not affected by PPI use, regardless of past history of colonic adenomatous polyps. |
topic |
colon polyps gastric polyps gastrin proton pump inhibitor |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X10700115 |
work_keys_str_mv |
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