Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate
Introduction Materials used for root canal obturation and root perforation are expected to have, in addition to preventing apical, lateral and coronary leakage, antimicrobial effects on microorganisms that are not accessible to chemomechanical instrumentation and intra-canal medications. The aim of...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Serbian Medical Society - Dental Section, Belgrade
2019-01-01
|
Series: | Stomatološki glasnik Srbije |
Subjects: | |
Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0039-1743/2019/0039-17431903113R.pdf |
id |
doaj-e0afa905aa8243bb898cb2b85f3c46fd |
---|---|
record_format |
Article |
spelling |
doaj-e0afa905aa8243bb898cb2b85f3c46fd2020-11-25T02:04:21ZengSerbian Medical Society - Dental Section, BelgradeStomatološki glasnik Srbije0039-17431452-37012019-01-016631131190039-17431903113RAntibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminateRadović Igor0Stojanović Nikola1Krunić Jelena2Davidović Lado3Lečić Jelena4https://orcid.org/0000-0003-4305-7288Jokanović Vukoman5https://orcid.org/0000-0002-2976-8238Živković Slavoljub6https://orcid.org/0000-0002-4512-1514University of East Sarajevo, Faculty of Medicine, Foča, Bosnia and HerzegovinaUniversity of East Sarajevo, Faculty of Medicine, Foča, Bosnia and HerzegovinaUniversity of East Sarajevo, Faculty of Medicine, Foča, Bosnia and HerzegovinaUniversity of East Sarajevo, Faculty of Medicine, Foča, Bosnia and HerzegovinaUniversity of East Sarajevo, Faculty of Medicine, Foča, Bosnia and HerzegovinaVinca Institute of Nuclear Sciences, Department of Atomic Physics, BelgradeUniversity of Belgrade, Faculty of Dental MedicineIntroduction Materials used for root canal obturation and root perforation are expected to have, in addition to preventing apical, lateral and coronary leakage, antimicrobial effects on microorganisms that are not accessible to chemomechanical instrumentation and intra-canal medications. The aim of this study was to evaluate the antimicrobial effect of a novel calcium aluminate-based endodontic nanostructured biomaterial (ALBO-MCCA) using agar diffusion test. Material and methods the two materials were tested in the study. The nanostructured calcium aluminate was synthesized by the hydrothermal sol-gel method from individual components of calcium aluminate (CaOxAl2 O3 ), calcite (CaCO3 ) and barium sulfate (BaSO4 ) as radiocontrast agent in the ratio of 2:2:1 according to V. Jokanovic's recipe. The other used material was calcium silicate MTA Angelus (Londrina, Brazil). The antimicrobial effect was assessed using agar diffusion test. Standard strains of Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, cultured on blood Mueller-Hinton agar and Candida albicans cultivated on Sabouraud Dextrose Agar, were used as test microorganisms. Results the best antimicrobial effect after 24 h both materials showed against S. aureus. The mean values of the growth inhibition zone for ALBO MCCA were 5.7 ± 0.25 mm and MTA 6.2 ± 0.4 mm. The ALBO MCCA material showed slightly stronger antibacterial effect against E. coli compared to MTA (p < 0.05), whereas none of the materials showed antibacterial effect against E. faecalis. Conclusion the ALBO MCCA material showed certain antibacterial effect on Escherichia coli, Staphylococcus aureus and Candida albicans that was comparable to antibacterial effect of MTA.https://scindeks-clanci.ceon.rs/data/pdf/0039-1743/2019/0039-17431903113R.pdfmineral trioxide aggregatecalcium aluminateantimicrobial effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Radović Igor Stojanović Nikola Krunić Jelena Davidović Lado Lečić Jelena Jokanović Vukoman Živković Slavoljub |
spellingShingle |
Radović Igor Stojanović Nikola Krunić Jelena Davidović Lado Lečić Jelena Jokanović Vukoman Živković Slavoljub Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate Stomatološki glasnik Srbije mineral trioxide aggregate calcium aluminate antimicrobial effect |
author_facet |
Radović Igor Stojanović Nikola Krunić Jelena Davidović Lado Lečić Jelena Jokanović Vukoman Živković Slavoljub |
author_sort |
Radović Igor |
title |
Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
title_short |
Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
title_full |
Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
title_fullStr |
Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
title_full_unstemmed |
Antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
title_sort |
antibacterial activity of newly synthesized endodontic nanomaterial based on calcium aluminate |
publisher |
Serbian Medical Society - Dental Section, Belgrade |
series |
Stomatološki glasnik Srbije |
issn |
0039-1743 1452-3701 |
publishDate |
2019-01-01 |
description |
Introduction Materials used for root canal obturation and root perforation are expected to have, in addition to preventing apical, lateral and coronary leakage, antimicrobial effects on microorganisms that are not accessible to chemomechanical instrumentation and intra-canal medications. The aim of this study was to evaluate the antimicrobial effect of a novel calcium aluminate-based endodontic nanostructured biomaterial (ALBO-MCCA) using agar diffusion test. Material and methods the two materials were tested in the study. The nanostructured calcium aluminate was synthesized by the hydrothermal sol-gel method from individual components of calcium aluminate (CaOxAl2 O3 ), calcite (CaCO3 ) and barium sulfate (BaSO4 ) as radiocontrast agent in the ratio of 2:2:1 according to V. Jokanovic's recipe. The other used material was calcium silicate MTA Angelus (Londrina, Brazil). The antimicrobial effect was assessed using agar diffusion test. Standard strains of Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, cultured on blood Mueller-Hinton agar and Candida albicans cultivated on Sabouraud Dextrose Agar, were used as test microorganisms. Results the best antimicrobial effect after 24 h both materials showed against S. aureus. The mean values of the growth inhibition zone for ALBO MCCA were 5.7 ± 0.25 mm and MTA 6.2 ± 0.4 mm. The ALBO MCCA material showed slightly stronger antibacterial effect against E. coli compared to MTA (p < 0.05), whereas none of the materials showed antibacterial effect against E. faecalis. Conclusion the ALBO MCCA material showed certain antibacterial effect on Escherichia coli, Staphylococcus aureus and Candida albicans that was comparable to antibacterial effect of MTA. |
topic |
mineral trioxide aggregate calcium aluminate antimicrobial effect |
url |
https://scindeks-clanci.ceon.rs/data/pdf/0039-1743/2019/0039-17431903113R.pdf |
work_keys_str_mv |
AT radovicigor antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT stojanovicnikola antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT krunicjelena antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT davidoviclado antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT lecicjelena antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT jokanovicvukoman antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate AT zivkovicslavoljub antibacterialactivityofnewlysynthesizedendodonticnanomaterialbasedoncalciumaluminate |
_version_ |
1724942893623279616 |