The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity

The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity

Transposable elements can be activated during germ cell maturation, potentially leading to genome instability and rewiring of the genetic circuitry. In this review, the authors discuss how the piRNA machinery suppresses these elements to ensure accurate spermatogenesis.

Bibliographic Details
Main Authors: Christina Ernst, Duncan T. Odom, Claudia Kutter
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01049-7
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spelling doaj-e0b3b4ef728c435a8cd07bd60478597a2021-05-11T07:10:54ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01049-7The emergence of piRNAs against transposon invasion to preserve mammalian genome integrityChristina Ernst0Duncan T. Odom1Claudia Kutter2University of Cambridge, Cancer Research UK Cambridge InstituteUniversity of Cambridge, Cancer Research UK Cambridge InstituteDepartment of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska InstituteTransposable elements can be activated during germ cell maturation, potentially leading to genome instability and rewiring of the genetic circuitry. In this review, the authors discuss how the piRNA machinery suppresses these elements to ensure accurate spermatogenesis.https://doi.org/10.1038/s41467-017-01049-7
collection DOAJ
language English
format Article
sources DOAJ
author Christina Ernst
Duncan T. Odom
Claudia Kutter
spellingShingle Christina Ernst
Duncan T. Odom
Claudia Kutter
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Nature Communications
author_facet Christina Ernst
Duncan T. Odom
Claudia Kutter
author_sort Christina Ernst
title The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_short The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_full The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_fullStr The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_full_unstemmed The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_sort emergence of pirnas against transposon invasion to preserve mammalian genome integrity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Transposable elements can be activated during germ cell maturation, potentially leading to genome instability and rewiring of the genetic circuitry. In this review, the authors discuss how the piRNA machinery suppresses these elements to ensure accurate spermatogenesis.
url https://doi.org/10.1038/s41467-017-01049-7
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