Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the <...

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Bibliographic Details
Main Authors: Armida W. M. Fabius, Milo van Hoefen Wijsard, Flora E. van Leeuwen, Annette C. Moll
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
Retinoblastoma
subsequent malignant neoplasms
second primary malignancies
trilateral Rb
heritable Rb
long-term surveillance
Online Access:https://www.mdpi.com/2072-6694/13/6/1200
Description
Summary:Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the <i>RB1 </i>tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.
ISSN:2072-6694

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