Subsequent Malignant Neoplasms in Retinoblastoma Survivors
Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the <...
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2021-03-01
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Online Access: | https://www.mdpi.com/2072-6694/13/6/1200 |
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doaj-e0b8d2df4e8741cc8786f712640f4c882021-03-11T00:02:37ZengMDPI AGCancers2072-66942021-03-01131200120010.3390/cancers13061200Subsequent Malignant Neoplasms in Retinoblastoma SurvivorsArmida W. M. Fabius0Milo van Hoefen Wijsard1Flora E. van Leeuwen2Annette C. Moll3Department of Ophthalmology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The NetherlandsDepartment of Ophthalmology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The NetherlandsDepartment of Epidemiology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The NetherlandsDepartment of Ophthalmology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The NetherlandsRetinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the <i>RB1 </i>tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.https://www.mdpi.com/2072-6694/13/6/1200Retinoblastomasubsequent malignant neoplasmssecond primary malignanciestrilateral Rbheritable Rblong-term surveillance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Armida W. M. Fabius Milo van Hoefen Wijsard Flora E. van Leeuwen Annette C. Moll |
spellingShingle |
Armida W. M. Fabius Milo van Hoefen Wijsard Flora E. van Leeuwen Annette C. Moll Subsequent Malignant Neoplasms in Retinoblastoma Survivors Cancers Retinoblastoma subsequent malignant neoplasms second primary malignancies trilateral Rb heritable Rb long-term surveillance |
author_facet |
Armida W. M. Fabius Milo van Hoefen Wijsard Flora E. van Leeuwen Annette C. Moll |
author_sort |
Armida W. M. Fabius |
title |
Subsequent Malignant Neoplasms in Retinoblastoma Survivors |
title_short |
Subsequent Malignant Neoplasms in Retinoblastoma Survivors |
title_full |
Subsequent Malignant Neoplasms in Retinoblastoma Survivors |
title_fullStr |
Subsequent Malignant Neoplasms in Retinoblastoma Survivors |
title_full_unstemmed |
Subsequent Malignant Neoplasms in Retinoblastoma Survivors |
title_sort |
subsequent malignant neoplasms in retinoblastoma survivors |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-03-01 |
description |
Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the <i>RB1 </i>tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed. |
topic |
Retinoblastoma subsequent malignant neoplasms second primary malignancies trilateral Rb heritable Rb long-term surveillance |
url |
https://www.mdpi.com/2072-6694/13/6/1200 |
work_keys_str_mv |
AT armidawmfabius subsequentmalignantneoplasmsinretinoblastomasurvivors AT milovanhoefenwijsard subsequentmalignantneoplasmsinretinoblastomasurvivors AT floraevanleeuwen subsequentmalignantneoplasmsinretinoblastomasurvivors AT annettecmoll subsequentmalignantneoplasmsinretinoblastomasurvivors |
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1724226404031135744 |