Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat
ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combinati...
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Instituto de Tecnologia do Paraná (Tecpar)
2015-12-01
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doaj-e0ba8dc731bd4ce19d4ae81ed487008c2020-11-24T22:14:44ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242015-12-0158683384210.1590/S1516-891320150232S1516-89132015000600833Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in RatNouf Al-RasheedLaila FaddahIman A SharafAzza M MohamedNawal Al-RasheedNayira AbdelbakyABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated DNA damaged and apoptosis markers in rat livers, proinflammatory markers including tumor necrosis factor- α (TNF- α) and C-reactive protein (CRP ) in rat livers as well as interleukin 6 (IL-6), interferon gamma (IFN-γ) and vascular endothelial growth factor (VEGF) in rat sera. These treatments also could ameliorated the alteration in cytochrome P450 2E1 (CYP2E1) activity in livers of CCl4 intoxicated rats as well as the increase in the serum alanine aminotransferase (ALT) compared with CCl4 intoxicated untreated rats. The present biochemical results are supported by histo-pathological examination. In conclusion, silymarin in a combination with vitamin E and curcumin was the most effective treatment in alleviating CCl4 induced liver damage and this may support the use of this combination as an effective treatment against liver damage induced by toxic agents.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600833&lng=en&tlng=enSilymarinVitamin ECurcuminCarbon Tetrachloride |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nouf Al-Rasheed Laila Faddah Iman A Sharaf Azza M Mohamed Nawal Al-Rasheed Nayira Abdelbaky |
spellingShingle |
Nouf Al-Rasheed Laila Faddah Iman A Sharaf Azza M Mohamed Nawal Al-Rasheed Nayira Abdelbaky Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat Brazilian Archives of Biology and Technology Silymarin Vitamin E Curcumin Carbon Tetrachloride |
author_facet |
Nouf Al-Rasheed Laila Faddah Iman A Sharaf Azza M Mohamed Nawal Al-Rasheed Nayira Abdelbaky |
author_sort |
Nouf Al-Rasheed |
title |
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat |
title_short |
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat |
title_full |
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat |
title_fullStr |
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat |
title_full_unstemmed |
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat |
title_sort |
assessment of the potential role of silymarin alone or in combination with vitamin e and/ or curcumin on the carbon tetrachloride induced liver injury in rat |
publisher |
Instituto de Tecnologia do Paraná (Tecpar) |
series |
Brazilian Archives of Biology and Technology |
issn |
1678-4324 |
publishDate |
2015-12-01 |
description |
ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated DNA damaged and apoptosis markers in rat livers, proinflammatory markers including tumor necrosis factor- α (TNF- α) and C-reactive protein (CRP ) in rat livers as well as interleukin 6 (IL-6), interferon gamma (IFN-γ) and vascular endothelial growth factor (VEGF) in rat sera. These treatments also could ameliorated the alteration in cytochrome P450 2E1 (CYP2E1) activity in livers of CCl4 intoxicated rats as well as the increase in the serum alanine aminotransferase (ALT) compared with CCl4 intoxicated untreated rats. The present biochemical results are supported by histo-pathological examination. In conclusion, silymarin in a combination with vitamin E and curcumin was the most effective treatment in alleviating CCl4 induced liver damage and this may support the use of this combination as an effective treatment against liver damage induced by toxic agents. |
topic |
Silymarin Vitamin E Curcumin Carbon Tetrachloride |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600833&lng=en&tlng=en |
work_keys_str_mv |
AT noufalrasheed assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat AT lailafaddah assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat AT imanasharaf assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat AT azzammohamed assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat AT nawalalrasheed assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat AT nayiraabdelbaky assessmentofthepotentialroleofsilymarinaloneorincombinationwithvitamineandorcurcuminonthecarbontetrachlorideinducedliverinjuryinrat |
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1725797305708183552 |