Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study
Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. C...
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doaj-e0bce2d201414cfa8b33a6f862efae6e2020-11-25T01:37:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-12-011010.3389/fphys.2019.01541491638Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling StudyNeeraj Saxena0Neeraj Saxena1Tommaso Gili2Tommaso Gili3Ana Diukova4Danielle Huckle5Judith E. Hall6Richard G. Wise7Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomDepartment of Anaesthetics, Intensive Care and Pain Medicine, Cwm Taf Morgannwg University Health Board, Llantrisant, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomIMT School for Advanced Studies Lucca, Lucca, ItalyCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomDepartment of Anaesthetics, University Hospital of Wales, Cardiff, United KingdomDepartment of Anaesthetics, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Cardiff, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomMechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. Cerebral perfusion change under an assumption of intact neurovascular coupling is an indicator of change in large-scale neural activity. In this experiment, we have investigated resting state cerebral blood flow (CBF) changes in the human brain during mild sedation, with propofol. Arterial spin labeling (ASL) provides a non-invasive, reliable, and robust means of measuring cerebral blood flow (CBF) and can therefore be used to investigate central drug effects. Mild propofol sedation-related CBF changes were studied at rest (n = 15), in a 3 T MR scanner using a PICORE-QUIPSS II ASL technique. CBF was reduced in bilateral paracingulate cortex, premotor cortex, Broca’s areas, right superior frontal gyrus and also the thalamus. This cerebral perfusion study demonstrates that propofol induces suppression of key cortical (frontal lobe) and subcortical (thalamus) regions during mild sedation.https://www.frontiersin.org/article/10.3389/fphys.2019.01541/fullarterial spin labelingfunctional magnetic resonance imagingcerebral blood flowpropofolsedation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neeraj Saxena Neeraj Saxena Tommaso Gili Tommaso Gili Ana Diukova Danielle Huckle Judith E. Hall Richard G. Wise |
spellingShingle |
Neeraj Saxena Neeraj Saxena Tommaso Gili Tommaso Gili Ana Diukova Danielle Huckle Judith E. Hall Richard G. Wise Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study Frontiers in Physiology arterial spin labeling functional magnetic resonance imaging cerebral blood flow propofol sedation |
author_facet |
Neeraj Saxena Neeraj Saxena Tommaso Gili Tommaso Gili Ana Diukova Danielle Huckle Judith E. Hall Richard G. Wise |
author_sort |
Neeraj Saxena |
title |
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study |
title_short |
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study |
title_full |
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study |
title_fullStr |
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study |
title_full_unstemmed |
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study |
title_sort |
mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: an arterial spin labeling study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2019-12-01 |
description |
Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. Cerebral perfusion change under an assumption of intact neurovascular coupling is an indicator of change in large-scale neural activity. In this experiment, we have investigated resting state cerebral blood flow (CBF) changes in the human brain during mild sedation, with propofol. Arterial spin labeling (ASL) provides a non-invasive, reliable, and robust means of measuring cerebral blood flow (CBF) and can therefore be used to investigate central drug effects. Mild propofol sedation-related CBF changes were studied at rest (n = 15), in a 3 T MR scanner using a PICORE-QUIPSS II ASL technique. CBF was reduced in bilateral paracingulate cortex, premotor cortex, Broca’s areas, right superior frontal gyrus and also the thalamus. This cerebral perfusion study demonstrates that propofol induces suppression of key cortical (frontal lobe) and subcortical (thalamus) regions during mild sedation. |
topic |
arterial spin labeling functional magnetic resonance imaging cerebral blood flow propofol sedation |
url |
https://www.frontiersin.org/article/10.3389/fphys.2019.01541/full |
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