Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including the bone cells, adi...
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doaj-e0be35a04abc4f2e8ebce4b8a184218a2020-11-25T01:38:34ZengMDPI AGBiomolecules2218-273X2020-02-0110233710.3390/biom10020337biom10020337Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone MicroenvironmentJennifer Zarrer0Marie-Therese Haider1Daniel J. Smit2Hanna Taipaleenmäki3Molecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyMolecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyMolecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyBone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including the bone cells, adipocytes, endothelial cells, and nerve cells that all have crucial functions in the maintenance of bone homeostasis. Tumor cells severely disturb the tightly controlled cellular and molecular interactions in the bone marrow fueling their own survival and growth. While the role of bone resorbing osteoclasts in breast cancer bone metastases is well established, the function of other bone cells, as well as adipocytes, endothelial cells, and nerve cells is less understood. In this review, we discuss the composition of the physiological bone microenvironment and how the presence of tumor cells influences the microenvironment, creating a pathological crosstalk between the cells. A better understanding of the cellular and molecular events that occur in the metastatic bone microenvironment could facilitate the identification of novel cellular targets to treat this devastating disease.https://www.mdpi.com/2218-273X/10/2/337breast cancerbone metastasesbone microenvironmentosteoclastosteoblastosteocyteadipocytevasculaturehypoxianerve cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jennifer Zarrer Marie-Therese Haider Daniel J. Smit Hanna Taipaleenmäki |
spellingShingle |
Jennifer Zarrer Marie-Therese Haider Daniel J. Smit Hanna Taipaleenmäki Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment Biomolecules breast cancer bone metastases bone microenvironment osteoclast osteoblast osteocyte adipocyte vasculature hypoxia nerve cells |
author_facet |
Jennifer Zarrer Marie-Therese Haider Daniel J. Smit Hanna Taipaleenmäki |
author_sort |
Jennifer Zarrer |
title |
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment |
title_short |
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment |
title_full |
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment |
title_fullStr |
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment |
title_full_unstemmed |
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment |
title_sort |
pathological crosstalk between metastatic breast cancer cells and the bone microenvironment |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2020-02-01 |
description |
Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including the bone cells, adipocytes, endothelial cells, and nerve cells that all have crucial functions in the maintenance of bone homeostasis. Tumor cells severely disturb the tightly controlled cellular and molecular interactions in the bone marrow fueling their own survival and growth. While the role of bone resorbing osteoclasts in breast cancer bone metastases is well established, the function of other bone cells, as well as adipocytes, endothelial cells, and nerve cells is less understood. In this review, we discuss the composition of the physiological bone microenvironment and how the presence of tumor cells influences the microenvironment, creating a pathological crosstalk between the cells. A better understanding of the cellular and molecular events that occur in the metastatic bone microenvironment could facilitate the identification of novel cellular targets to treat this devastating disease. |
topic |
breast cancer bone metastases bone microenvironment osteoclast osteoblast osteocyte adipocyte vasculature hypoxia nerve cells |
url |
https://www.mdpi.com/2218-273X/10/2/337 |
work_keys_str_mv |
AT jenniferzarrer pathologicalcrosstalkbetweenmetastaticbreastcancercellsandthebonemicroenvironment AT marietheresehaider pathologicalcrosstalkbetweenmetastaticbreastcancercellsandthebonemicroenvironment AT danieljsmit pathologicalcrosstalkbetweenmetastaticbreastcancercellsandthebonemicroenvironment AT hannataipaleenmaki pathologicalcrosstalkbetweenmetastaticbreastcancercellsandthebonemicroenvironment |
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