Metabolic predictors of individual immune responses to adaptogenic balneotherapy

• Main Authors: Zoryana Struk, Oksana Mel’nyk, Walery Zukow, Igor Popovych
• Format: Article
• Language: English
• Published: Kazimierz Wielki University 2020-02-01
• Series: Journal of Education, Health and Sport
• Subjects: electrolytes; nitrous and lipoproteins parameters; cholekinetics; immunity.
• Online Access: https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/29699

<p style="margin-left: 0cm; text-indent: 0cm; margin-bottom: 0cm; line-height: 100%; background: #f8f9fa;" lang="ru-RU" align="justify"><span style="font-family: 'Courier New', monospace;"><span style="font-size: 10pt;"><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"><strong>Background.</strong></span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"> Earlier</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en"> four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably (with an accuracy of 97,7%) predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters a</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">s well as</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en"> erythrocyturia. In the next study discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. The </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en"><strong>purpose</strong></span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en"> of this study is to search for predictors of immune responses among the registered Metabolic parameters. </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"><strong>Material and methods. </strong></span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">The</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">object</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">of</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">observation</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">were</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"> 34</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">men</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">and</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"> 10 </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">women</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">aged</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">24-70</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">years</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">old</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">,</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">who</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">came</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">to</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">the</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">Truskavets</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">’ </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">spa</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"> for the treatment </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">of chronic pyelonephritis combined with</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">cholecystitis in</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">remission</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">. We </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">determined them the</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">Electrokinetic index</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">, Lipoproteines spectrum, plasma and daily urine levels of Electrolytes and Nitrous metabolites as well as basal and postprandial </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">volume </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">of gall-bladder. </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"><strong>Results.</strong></span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en"> Discriminant analysis</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">revealed 16 parameters as the predictors. Of these, 3 reflect the level of Plasma Electrolytes, 5 - the Urine Electrolytes, another 2 - the levels of plasma and urine Urea. Other predictors were: Very Low Density Lipoprotein Cholesterol plasma level, Body Mass index, fasting gallbladder volume and 30 minutes after cholekinetics, Electrokinetic index, and patient Age</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US">. These predictors</span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">, taken together, determine the nature of the immune response with an accuracy of 95,5%. </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en-US"><strong>Conclusion</strong></span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="uk-UA">. </span></span></span></span><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: 12pt;"><span lang="en">The variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism, as well as the age and sex of patients.</span></span></span></span></span></span></p>