Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. M...
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doaj-e0d55def843a424683bf1ff0b0ea1e032021-07-06T11:30:10ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-0127133434310.1080/10717544.2020.17242101724210Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrinYili Ding0Yuchang Pang1Chamakura V. N. S. Vara Prasad2Bingyun Wang3Life Science Department, Foshan UniversityLife Science Department, Foshan UniversityDas PharmaLife Science Department, Foshan UniversityEnrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD.http://dx.doi.org/10.1080/10717544.2020.1724210enrofloxacin2-hydroxypropyl-β-cyclodextrininclusion complexpreparationpharmaceutical properties |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yili Ding Yuchang Pang Chamakura V. N. S. Vara Prasad Bingyun Wang |
spellingShingle |
Yili Ding Yuchang Pang Chamakura V. N. S. Vara Prasad Bingyun Wang Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin Drug Delivery enrofloxacin 2-hydroxypropyl-β-cyclodextrin inclusion complex preparation pharmaceutical properties |
author_facet |
Yili Ding Yuchang Pang Chamakura V. N. S. Vara Prasad Bingyun Wang |
author_sort |
Yili Ding |
title |
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
title_short |
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
title_full |
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
title_fullStr |
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
title_full_unstemmed |
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
title_sort |
formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin |
publisher |
Taylor & Francis Group |
series |
Drug Delivery |
issn |
1071-7544 1521-0464 |
publishDate |
2020-01-01 |
description |
Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD. |
topic |
enrofloxacin 2-hydroxypropyl-β-cyclodextrin inclusion complex preparation pharmaceutical properties |
url |
http://dx.doi.org/10.1080/10717544.2020.1724210 |
work_keys_str_mv |
AT yiliding formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin AT yuchangpang formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin AT chamakuravnsvaraprasad formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin AT bingyunwang formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin |
_version_ |
1721317704197996544 |