Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin

• Main Authors: Yili Ding, Yuchang Pang, Chamakura V. N. S. Vara Prasad, Bingyun Wang
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2020-01-01
• Series: Drug Delivery
• Subjects: enrofloxacin; 2-hydroxypropyl-β-cyclodextrin; inclusion complex; preparation; pharmaceutical properties
• Online Access: http://dx.doi.org/10.1080/10717544.2020.1724210

Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD.