Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin

Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. M...

Full description

Bibliographic Details
Main Authors: Yili Ding, Yuchang Pang, Chamakura V. N. S. Vara Prasad, Bingyun Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
Online Access:http://dx.doi.org/10.1080/10717544.2020.1724210
id doaj-e0d55def843a424683bf1ff0b0ea1e03
record_format Article
spelling doaj-e0d55def843a424683bf1ff0b0ea1e032021-07-06T11:30:10ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-0127133434310.1080/10717544.2020.17242101724210Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrinYili Ding0Yuchang Pang1Chamakura V. N. S. Vara Prasad2Bingyun Wang3Life Science Department, Foshan UniversityLife Science Department, Foshan UniversityDas PharmaLife Science Department, Foshan UniversityEnrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD.http://dx.doi.org/10.1080/10717544.2020.1724210enrofloxacin2-hydroxypropyl-β-cyclodextrininclusion complexpreparationpharmaceutical properties
collection DOAJ
language English
format Article
sources DOAJ
author Yili Ding
Yuchang Pang
Chamakura V. N. S. Vara Prasad
Bingyun Wang
spellingShingle Yili Ding
Yuchang Pang
Chamakura V. N. S. Vara Prasad
Bingyun Wang
Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
Drug Delivery
enrofloxacin
2-hydroxypropyl-β-cyclodextrin
inclusion complex
preparation
pharmaceutical properties
author_facet Yili Ding
Yuchang Pang
Chamakura V. N. S. Vara Prasad
Bingyun Wang
author_sort Yili Ding
title Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
title_short Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
title_full Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
title_fullStr Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
title_full_unstemmed Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
title_sort formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
publisher Taylor & Francis Group
series Drug Delivery
issn 1071-7544
1521-0464
publishDate 2020-01-01
description Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-β-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-β-CD.
topic enrofloxacin
2-hydroxypropyl-β-cyclodextrin
inclusion complex
preparation
pharmaceutical properties
url http://dx.doi.org/10.1080/10717544.2020.1724210
work_keys_str_mv AT yiliding formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin
AT yuchangpang formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin
AT chamakuravnsvaraprasad formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin
AT bingyunwang formationofinclusioncomplexofenrofloxacinwith2hydroxypropylbcyclodextrin
_version_ 1721317704197996544