Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension
Idiopathic pulmonary arterial hypertension is a rare disease with unknown etiology, characterized by progressive increase in pulmonary vessel resistance, right heart failure. Combined pathogenetic therapy using leads to depression of disease progression, repeated hospitalization, improvement in dise...
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IP Morozov P.V.
2015-06-01
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doaj-e0e6907d27e84c9a81af5f456f4c99a52020-11-25T03:13:12ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892015-06-01122667026178Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertensionI N Zavyrylina0O A Arkhipova1M A Saidova2N M Danylov3T V Martynyuk4I E Chazova5A.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian FederationIdiopathic pulmonary arterial hypertension is a rare disease with unknown etiology, characterized by progressive increase in pulmonary vessel resistance, right heart failure. Combined pathogenetic therapy using leads to depression of disease progression, repeated hospitalization, improvement in disease prognosis in patients with III-IV functional class (WHO).The patient with diagnosis of idiopathic pulmonary arterial hypertension, verified by right heart catheterization method, functional class III (WHO) was treated by anticoagulants, diuretics. There were observed the negative dynamic with right heart chambers dilation, appearing of heart failure signs during the treatment with phosphodiesterase type 5-inhibitor sildenafil. After adding an inhaled form of prostanoids-iloprost to sildenafil therapy there was achieved the significant improvement of the functional and hemodynamic status. Reduction in dyspnoea level, improvement in physical activity tolerance and disease prognosis were reached.https://syst-hypertension.ru/2075-082X/article/viewFile/29077/pdfidiopathic pulmonary arterial hypertensionphosphodiesterase type 5 inhibitorsildenafilprostanoidsiloprost |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I N Zavyrylina O A Arkhipova M A Saidova N M Danylov T V Martynyuk I E Chazova |
spellingShingle |
I N Zavyrylina O A Arkhipova M A Saidova N M Danylov T V Martynyuk I E Chazova Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension Системные гипертензии idiopathic pulmonary arterial hypertension phosphodiesterase type 5 inhibitor sildenafil prostanoids iloprost |
author_facet |
I N Zavyrylina O A Arkhipova M A Saidova N M Danylov T V Martynyuk I E Chazova |
author_sort |
I N Zavyrylina |
title |
Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
title_short |
Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
title_full |
Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
title_fullStr |
Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
title_full_unstemmed |
Clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
title_sort |
clinical case: combination therapy with iloprost and sildenafil in the treatment of idiopathic pulmonary hypertension |
publisher |
IP Morozov P.V. |
series |
Системные гипертензии |
issn |
2075-082X 2542-2189 |
publishDate |
2015-06-01 |
description |
Idiopathic pulmonary arterial hypertension is a rare disease with unknown etiology, characterized by progressive increase in pulmonary vessel resistance, right heart failure. Combined pathogenetic therapy using leads to depression of disease progression, repeated hospitalization, improvement in disease prognosis in patients with III-IV functional class (WHO).The patient with diagnosis of idiopathic pulmonary arterial hypertension, verified by right heart catheterization method, functional class III (WHO) was treated by anticoagulants, diuretics. There were observed the negative dynamic with right heart chambers dilation, appearing of heart failure signs during the treatment with phosphodiesterase type 5-inhibitor sildenafil. After adding an inhaled form of prostanoids-iloprost to sildenafil therapy there was achieved the significant improvement of the functional and hemodynamic status. Reduction in dyspnoea level, improvement in physical activity tolerance and disease prognosis were reached. |
topic |
idiopathic pulmonary arterial hypertension phosphodiesterase type 5 inhibitor sildenafil prostanoids iloprost |
url |
https://syst-hypertension.ru/2075-082X/article/viewFile/29077/pdf |
work_keys_str_mv |
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