Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was though...
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doaj-e0e85f2297a648769a208cba636ee4aa2020-11-25T04:04:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218870887010.3390/ijms21228870Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of ActionJakub Mlost0Marta Bryk1Katarzyna Starowicz2Department of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, PolandDepartment of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, PolandDepartment of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, PolandCannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of cannabis. Numerous anecdotal findings testify to the therapeutic effects of CBD, which in some cases were further supported by research findings. However, data regarding CBD’s mechanism of action and therapeutic potential are abundant and omnifarious. Therefore, we review the basic research regarding molecular mechanism of CBD’s action with particular focus on its analgesic potential. Moreover, this article describes the detailed analgesic and anti-inflammatory effects of CBD in various models, including neuropathic pain, inflammatory pain, osteoarthritis and others. The dose and route of the administration-dependent effect of CBD, on the reduction in pain, hyperalgesia or allodynia, as well as the production of pro and anti-inflammatory cytokines, were described depending on the disease model. The clinical applications of CBD-containing drugs are also mentioned. The data presented herein unravel what is known about CBD’s pharmacodynamics and analgesic effects to provide the reader with current state-of-art knowledge regarding CBD’s action and future perspectives for research.https://www.mdpi.com/1422-0067/21/22/8870CBDnetwork pharmacologypainneuropathicosteoarthritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jakub Mlost Marta Bryk Katarzyna Starowicz |
spellingShingle |
Jakub Mlost Marta Bryk Katarzyna Starowicz Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action International Journal of Molecular Sciences CBD network pharmacology pain neuropathic osteoarthritis |
author_facet |
Jakub Mlost Marta Bryk Katarzyna Starowicz |
author_sort |
Jakub Mlost |
title |
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action |
title_short |
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action |
title_full |
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action |
title_fullStr |
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action |
title_full_unstemmed |
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action |
title_sort |
cannabidiol for pain treatment: focus on pharmacology and mechanism of action |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of cannabis. Numerous anecdotal findings testify to the therapeutic effects of CBD, which in some cases were further supported by research findings. However, data regarding CBD’s mechanism of action and therapeutic potential are abundant and omnifarious. Therefore, we review the basic research regarding molecular mechanism of CBD’s action with particular focus on its analgesic potential. Moreover, this article describes the detailed analgesic and anti-inflammatory effects of CBD in various models, including neuropathic pain, inflammatory pain, osteoarthritis and others. The dose and route of the administration-dependent effect of CBD, on the reduction in pain, hyperalgesia or allodynia, as well as the production of pro and anti-inflammatory cytokines, were described depending on the disease model. The clinical applications of CBD-containing drugs are also mentioned. The data presented herein unravel what is known about CBD’s pharmacodynamics and analgesic effects to provide the reader with current state-of-art knowledge regarding CBD’s action and future perspectives for research. |
topic |
CBD network pharmacology pain neuropathic osteoarthritis |
url |
https://www.mdpi.com/1422-0067/21/22/8870 |
work_keys_str_mv |
AT jakubmlost cannabidiolforpaintreatmentfocusonpharmacologyandmechanismofaction AT martabryk cannabidiolforpaintreatmentfocusonpharmacologyandmechanismofaction AT katarzynastarowicz cannabidiolforpaintreatmentfocusonpharmacologyandmechanismofaction |
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