Serum Metabolomics in PCOS Women with Different Body Mass Index
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder, affecting 5–10% of women of reproductive age. It results from complex environmental factors, genetic predisposition, hyperinsulinemia, hormonal imbalance, neuroendocrine abnormalities, chronic inflammation, and...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/10/13/2811 |
id |
doaj-e0ec3c853e004b6aaba28bd43e4597e3 |
---|---|
record_format |
Article |
spelling |
doaj-e0ec3c853e004b6aaba28bd43e4597e32021-07-15T15:39:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-01102811281110.3390/jcm10132811Serum Metabolomics in PCOS Women with Different Body Mass IndexKatarzyna Ożegowska0Szymon Plewa1Urszula Mantaj2Leszek Pawelczyk3Jan Matysiak4Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 61-701 Poznań, PolandDivision of Reproduction, Medical Faculty I, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 61-701 Poznań, PolandPolycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder, affecting 5–10% of women of reproductive age. It results from complex environmental factors, genetic predisposition, hyperinsulinemia, hormonal imbalance, neuroendocrine abnormalities, chronic inflammation, and autoimmune disorders. PCOS impacts menstrual regularities, fertility, and dermatological complications, and may induce metabolic disturbances, diabetes, and coronary heart disease. Comprehensive metabolic profiling of patients with PCOS may be a big step in understanding and treating the disease. The study aimed to search for potential differences in metabolites concentrations among women with PCOS according to different body mass index (BMI) in comparison to healthy controls. We used broad-spectrum targeted metabolomics to evaluate metabolites’ serum concentrations in PCOS patients and compared them with healthy controls. The measurements were performed using high-performance liquid chromatography coupled with the triple quadrupole tandem mass spectrometry technique, which has highly selective multiple reaction monitoring modes. The main differences were found in glycerophospholipid concentrations, with no specific tendency to up-or down-regulation. Insulin resistance and elevated body weight influence acylcarnitine C2 levels more than PCOS itself. Sphingomyelin (SM) C18:1 should be more intensively observed and examined in future studies and maybe serve as one of the PCOS biomarkers. No significant correlations were observed between anthropometric and hormonal parameters and metabolome results.https://www.mdpi.com/2077-0383/10/13/2811polycystic ovary syndromemetabolomemetabolic disturbancesbody mass indexinsulin resistancemetabolic pathways |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katarzyna Ożegowska Szymon Plewa Urszula Mantaj Leszek Pawelczyk Jan Matysiak |
spellingShingle |
Katarzyna Ożegowska Szymon Plewa Urszula Mantaj Leszek Pawelczyk Jan Matysiak Serum Metabolomics in PCOS Women with Different Body Mass Index Journal of Clinical Medicine polycystic ovary syndrome metabolome metabolic disturbances body mass index insulin resistance metabolic pathways |
author_facet |
Katarzyna Ożegowska Szymon Plewa Urszula Mantaj Leszek Pawelczyk Jan Matysiak |
author_sort |
Katarzyna Ożegowska |
title |
Serum Metabolomics in PCOS Women with Different Body Mass Index |
title_short |
Serum Metabolomics in PCOS Women with Different Body Mass Index |
title_full |
Serum Metabolomics in PCOS Women with Different Body Mass Index |
title_fullStr |
Serum Metabolomics in PCOS Women with Different Body Mass Index |
title_full_unstemmed |
Serum Metabolomics in PCOS Women with Different Body Mass Index |
title_sort |
serum metabolomics in pcos women with different body mass index |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-06-01 |
description |
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder, affecting 5–10% of women of reproductive age. It results from complex environmental factors, genetic predisposition, hyperinsulinemia, hormonal imbalance, neuroendocrine abnormalities, chronic inflammation, and autoimmune disorders. PCOS impacts menstrual regularities, fertility, and dermatological complications, and may induce metabolic disturbances, diabetes, and coronary heart disease. Comprehensive metabolic profiling of patients with PCOS may be a big step in understanding and treating the disease. The study aimed to search for potential differences in metabolites concentrations among women with PCOS according to different body mass index (BMI) in comparison to healthy controls. We used broad-spectrum targeted metabolomics to evaluate metabolites’ serum concentrations in PCOS patients and compared them with healthy controls. The measurements were performed using high-performance liquid chromatography coupled with the triple quadrupole tandem mass spectrometry technique, which has highly selective multiple reaction monitoring modes. The main differences were found in glycerophospholipid concentrations, with no specific tendency to up-or down-regulation. Insulin resistance and elevated body weight influence acylcarnitine C2 levels more than PCOS itself. Sphingomyelin (SM) C18:1 should be more intensively observed and examined in future studies and maybe serve as one of the PCOS biomarkers. No significant correlations were observed between anthropometric and hormonal parameters and metabolome results. |
topic |
polycystic ovary syndrome metabolome metabolic disturbances body mass index insulin resistance metabolic pathways |
url |
https://www.mdpi.com/2077-0383/10/13/2811 |
work_keys_str_mv |
AT katarzynaozegowska serummetabolomicsinpcoswomenwithdifferentbodymassindex AT szymonplewa serummetabolomicsinpcoswomenwithdifferentbodymassindex AT urszulamantaj serummetabolomicsinpcoswomenwithdifferentbodymassindex AT leszekpawelczyk serummetabolomicsinpcoswomenwithdifferentbodymassindex AT janmatysiak serummetabolomicsinpcoswomenwithdifferentbodymassindex |
_version_ |
1721299152518774784 |