Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes
Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-...
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doaj-e0ee3f11847f4e08a8b47ad230f2b1bf2021-07-23T13:51:30ZengMDPI AGMaterials1996-19442021-07-01143854385410.3390/ma14143854Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based BiomicroconcretesJoanna Czechowska0Ewelina Cichoń1Anna Belcarz2Anna Ślósarczyk3Aneta Zima4Department of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Av., 30-059 Krakow, PolandDepartment of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Av., 30-059 Krakow, PolandChair and Department of Biochemistry and Biotechnology, Medical University in Lublin, Chodzki 1, 20-093 Lublin, PolandDepartment of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Av., 30-059 Krakow, PolandDepartment of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Av., 30-059 Krakow, PolandBioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against <i>S. epidermidis</i>, <i>E. coli</i>, and <i>S. aureus</i> was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies.https://www.mdpi.com/1996-1944/14/14/3854biomicroconcretesgold nanoparticlessilicon |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Czechowska Ewelina Cichoń Anna Belcarz Anna Ślósarczyk Aneta Zima |
spellingShingle |
Joanna Czechowska Ewelina Cichoń Anna Belcarz Anna Ślósarczyk Aneta Zima Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes Materials biomicroconcretes gold nanoparticles silicon |
author_facet |
Joanna Czechowska Ewelina Cichoń Anna Belcarz Anna Ślósarczyk Aneta Zima |
author_sort |
Joanna Czechowska |
title |
Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes |
title_short |
Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes |
title_full |
Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes |
title_fullStr |
Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes |
title_full_unstemmed |
Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes |
title_sort |
effect of gold nanoparticles and silicon on the bioactivity and antibacterial properties of hydroxyapatite/chitosan/tricalcium phosphate-based biomicroconcretes |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2021-07-01 |
description |
Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against <i>S. epidermidis</i>, <i>E. coli</i>, and <i>S. aureus</i> was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies. |
topic |
biomicroconcretes gold nanoparticles silicon |
url |
https://www.mdpi.com/1996-1944/14/14/3854 |
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