Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
Neuroinflammation contributes to amyotrophic lateral sclerosis (ALS) progression. TLR4, a transmembrane protein that plays a central role in activation of the innate immune system, has been shown to induce microglial activation in ALS models. TLR4 is up-regulated in the spinal cords of hSOD1G93A mic...
Main Authors: | Avi Fellner, Yael Barhum, Ariel Angel, Nisim Perets, Israel Steiner, Daniel Offen, Nirit Lev |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/18/8/1666 |
Similar Items
-
TAK-242 Protects Against Apoptosis in Coronary Microembolization-Induced Myocardial Injury in Rats by Suppressing TLR4/NF-κB Signaling Pathway
by: Xian-tao Wang, et al.
Published: (2017-03-01) -
Effect of TAK-242 on Proliferation and Apoptosis of Human Multiple Myeloma Cells
by: DUAN Pingping, et al.
Published: (2019-04-01) -
Inhibitive effect of TAK-242 on Tenon’s capsule fibroblasts proliferation in rat eyes
by: Liang Liang, et al.
Published: (2019-11-01) -
Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug
by: Snigdha Samarpita, et al.
Published: (2020-01-01) -
TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway
by: Jiajia Wang, et al.
Published: (2020-08-01)