| Summary: | Periodontal disease affects the supporting tissues of the teeth, being a chronic inflammatory disease caused by specific microorganisms from subgingival biofilm. <i>Fusobacterium nucleatum</i> is a Gram-negative anaerobic bacterium that acts as a periodontal pathogen, being an important factor in linking Gram-positive and Gram-negative bacteria in the periodontal biofilm, but its involvement in systemic diseases has also been found. Several studies regarding the implication of <i>Fusobacterium nucleatum</i> in gastro-enterological cancers have been conducted. The present review aims to update and systematize the latest information about <i>Fusobacterium nucleatum</i> in order to evaluate the possibility of an association between periodontal disease and the evolution of gastroenterological cancers through the action of <i>Fusobacterium nucleatum</i>, highlighting gastric cancer. This would motivate future research on the negative influence of periodontal pathology on the evolution of gastric cancer in patients suffering from both pathologies.
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