Evaluation of Interleukin 1β in Febrile Convulsion
Febrile convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. T...
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Tehran University of Medical Sciences
2012-12-01
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doaj-e0ffe99477ed4d75a1a0b7513da84ceb2020-11-25T04:12:32ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492012-12-01114508Evaluation of Interleukin 1β in Febrile ConvulsionFatemeh Behmanesh0Farah Ashrafzadeh1Abdoreza Varasteh2Abdoreza Shakeri3Shabnam Shahsavand4Allergy Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pediatric Neurology, Faculty of Medicine, University of Medical Sciences, Mashhad, IranDepartment of Immunology and Allergy, Faculty of Medicine, University of Medical Sciences, Mashhad, IranDepartment of Pediatrics, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, IranDepartment of Molecular Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Febrile convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. Thus we measured IL-1ß in febrile children with or without seizure. 60 febrile children (6 months to 5 years old) were divided in two groups, one group consisted of 30 children with FC, the other group consisting of 30 children without seizure which served as control. Blood samples were collected from members of both groups and serum samples were prepared. Interleukin 1β concentrations were measured using a commercial Enzyme-linked immunosorbent assay (ELISA) kit. We found that there was a difference in serum levels of Interleukin 1β between FC and control group but it was not significant. This result may be due to the low number of samples or the result of Interleukin 1β binding to some large proteins such as α2- macroglobolin, complement and soluble type 2 Interleukin 1 receptor, that affected the free Interleukin 1β concentration. We could not find a significant relationship between serum Interleukin 1β concentration and FC. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/543ChildrenFebrile convulsionInterleukin 1β |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Behmanesh Farah Ashrafzadeh Abdoreza Varasteh Abdoreza Shakeri Shabnam Shahsavand |
spellingShingle |
Fatemeh Behmanesh Farah Ashrafzadeh Abdoreza Varasteh Abdoreza Shakeri Shabnam Shahsavand Evaluation of Interleukin 1β in Febrile Convulsion Iranian Journal of Allergy, Asthma and Immunology Children Febrile convulsion Interleukin 1β |
author_facet |
Fatemeh Behmanesh Farah Ashrafzadeh Abdoreza Varasteh Abdoreza Shakeri Shabnam Shahsavand |
author_sort |
Fatemeh Behmanesh |
title |
Evaluation of Interleukin 1β in Febrile Convulsion |
title_short |
Evaluation of Interleukin 1β in Febrile Convulsion |
title_full |
Evaluation of Interleukin 1β in Febrile Convulsion |
title_fullStr |
Evaluation of Interleukin 1β in Febrile Convulsion |
title_full_unstemmed |
Evaluation of Interleukin 1β in Febrile Convulsion |
title_sort |
evaluation of interleukin 1β in febrile convulsion |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2012-12-01 |
description |
Febrile convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. Thus we measured IL-1ß in febrile children with or without seizure.
60 febrile children (6 months to 5 years old) were divided in two groups, one group consisted of 30 children with FC, the other group consisting of 30 children without seizure which served as control. Blood samples were collected from members of both groups and serum samples were prepared. Interleukin 1β concentrations were measured using a commercial Enzyme-linked immunosorbent assay (ELISA) kit.
We found that there was a difference in serum levels of Interleukin 1β between FC and control group but it was not significant. This result may be due to the low number of samples or the result of Interleukin 1β binding to some large proteins such as α2- macroglobolin, complement and soluble type 2 Interleukin 1 receptor, that affected the free Interleukin 1β concentration.
We could not find a significant relationship between serum Interleukin 1β concentration and FC.
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topic |
Children Febrile convulsion Interleukin 1β |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/543 |
work_keys_str_mv |
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