Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity

Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity

Summary: CANTOS (Canakinumab Antiinflammatory Thrombosis Outcome Study) confirmed interleukin (IL)–1β as an appealing therapeutic target for human atherosclerosis and related complications. However, there are serious gaps in our understanding of IL-1 production in atherosclerosis. Herein the authors...

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Bibliographic Details
Main Authors:	Xintong Jiang, MD, Feilong Wang, MD, Yajuan Wang, MD, PhD, Anton Gisterå, MD, PhD, Joy Roy, MD, PhD, Gabrielle Paulsson-Berne, PhD, Ulf Hedin, MD, PhD, Amir Lerman, MD, Göran K. Hansson, MD, PhD, Joerg Herrmann, MD, Zhong-qun Yan, MD, PhD
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	JACC: Basic to Translational Science
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452302X19300683

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