Pharmacological inactivation of the prion protein by targeting a folding intermediate

Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizi...

Full description

Bibliographic Details
Main Authors:	Giovanni Spagnolli, Tania Massignan, Andrea Astolfi, Silvia Biggi, Marta Rigoli, Paolo Brunelli, Michela Libergoli, Alan Ianeselli, Simone Orioli, Alberto Boldrini, Luca Terruzzi, Valerio Bonaldo, Giulia Maietta, Nuria L. Lorenzo, Leticia C. Fernandez, Yaiza B. Codeseira, Laura Tosatto, Luise Linsenmeier, Beatrice Vignoli, Gianluca Petris, Dino Gasparotto, Maria Pennuto, Graziano Guella, Marco Canossa, Hermann C. Altmeppen, Graziano Lolli, Stefano Biressi, Manuel M. Pastor, Jesús R. Requena, Ines Mancini, Maria L. Barreca, Pietro Faccioli, Emiliano Biasini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-020-01585-x

id	doaj-e109df8e1973483785b0d57e6d79e2af
record_format	Article
spelling	doaj-e109df8e1973483785b0d57e6d79e2af2021-01-17T12:27:08ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111610.1038/s42003-020-01585-xPharmacological inactivation of the prion protein by targeting a folding intermediateGiovanni Spagnolli0Tania Massignan1Andrea Astolfi2Silvia Biggi3Marta Rigoli4Paolo Brunelli5Michela Libergoli6Alan Ianeselli7Simone Orioli8Alberto Boldrini9Luca Terruzzi10Valerio Bonaldo11Giulia Maietta12Nuria L. Lorenzo13Leticia C. Fernandez14Yaiza B. Codeseira15Laura Tosatto16Luise Linsenmeier17Beatrice Vignoli18Gianluca Petris19Dino Gasparotto20Maria Pennuto21Graziano Guella22Marco Canossa23Hermann C. Altmeppen24Graziano Lolli25Stefano Biressi26Manuel M. Pastor27Jesús R. Requena28Ines Mancini29Maria L. Barreca30Pietro Faccioli31Emiliano Biasini32Department of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Pharmaceutical Sciences, University of PerugiaDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Physics, University of Trento, PovoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Physics, University of Trento, PovoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDISCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDISCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDISInstitute of Biophysics, National Council of Research, 38123 PovoInstitute of Neuropathology, University Medical Center Hamburg-EppendorfDepartment of Physics, University of Trento, PovoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Biomedical Sciences (DBS), University of PadovaDepartment of Physics, University of Trento, PovoDepartment of Cellular, Computational and Integrative Biology, University of TrentoInstitute of Neuropathology, University Medical Center Hamburg-EppendorfDepartment of Cellular, Computational and Integrative Biology, University of TrentoDepartment of Cellular, Computational and Integrative Biology, University of TrentoRIAIDT, University of Santiago de Compostela-IDISCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDISDepartment of Physics, University of Trento, PovoDepartment of Pharmaceutical Sciences, University of PerugiaDepartment of Physics, University of Trento, PovoDepartment of Cellular, Computational and Integrative Biology, University of TrentoSpagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.https://doi.org/10.1038/s42003-020-01585-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini
spellingShingle	Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini Pharmacological inactivation of the prion protein by targeting a folding intermediate Communications Biology
author_facet	Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini
author_sort	Giovanni Spagnolli
title	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_short	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_full	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_fullStr	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_full_unstemmed	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_sort	pharmacological inactivation of the prion protein by targeting a folding intermediate
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-01-01
description	Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.
url	https://doi.org/10.1038/s42003-020-01585-x
work_keys_str_mv	AT giovannispagnolli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT taniamassignan pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT andreaastolfi pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT silviabiggi pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT martarigoli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT paolobrunelli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT michelalibergoli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT alanianeselli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT simoneorioli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT albertoboldrini pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT lucaterruzzi pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT valeriobonaldo pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT giuliamaietta pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT nuriallorenzo pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT leticiacfernandez pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT yaizabcodeseira pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT lauratosatto pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT luiselinsenmeier pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT beatricevignoli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT gianlucapetris pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT dinogasparotto pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT mariapennuto pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT grazianoguella pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT marcocanossa pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT hermanncaltmeppen pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT grazianololli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT stefanobiressi pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT manuelmpastor pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT jesusrrequena pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT inesmancini pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT marialbarreca pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT pietrofaccioli pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate AT emilianobiasini pharmacologicalinactivationoftheprionproteinbytargetingafoldingintermediate
_version_	1724334935376920576

Pharmacological inactivation of the prion protein by targeting a folding intermediate

Similar Items