A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

Background: Current immunodiagnostic tests for tuberculosis (TB) are based on the detection of an immune response toward mycobacterial antigens injected into the skin or following an in-vitro simulation in interferon gamma-release assays. Both tests have limited sensitivity and are unable to differe...

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Bibliographic Details
Main Authors: Noëmi R. Meier, Marc Jacobsen, Tom H. M. Ottenhoff, Nicole Ritz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
interferon gamma-release assay
immune-response
clinical studies
active tuberculosis
latent tuberculosis
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02476/full

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