Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model.
Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derive...
Main Authors: | Jennifer A MacDiarmid, Veronika Langova, Dale Bailey, Scott T Pattison, Stacey L Pattison, Neil Christensen, Luke R Armstrong, Vatsala N Brahmbhatt, Katarzyna Smolarczyk, Matthew T Harrison, Marylia Costa, Nancy B Mugridge, Ilya Sedliarou, Nicholas A Grimes, Debra L Kiss, Bruce Stillman, Christine L Hann, Gary L Gallia, Robert M Graham, Himanshu Brahmbhatt |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4822833?pdf=render |
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