Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer
Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive abili...
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China Medical University
2019-12-01
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doaj-e1384afca8e1453886ed925463480ae02020-11-25T03:00:42ZengChina Medical UniversityBioMedicine2211-80392019-12-01942210.1051/bmdcn/2019090422bmdcn2019090422Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancerBabaei KosarKhaksar RoyaZeinali TaherehHemmati HosseinBandegi AhmadrezaSamidoust PirouzAshoobi Mohammad TaghiHashemian HoomanDelpasand KouroshTalebinasab FereshtehNaebi HooraMirpour Seyed HosseinKeymoradzadeh ArmanNorollahi Seyedeh ElhamColorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly if the gene was become silenced, leaving the mechanisms of methylation without any response. According to the methylation situation which has a strong eagerness to be highly altered on CpG islands in carcinogenesis and tumorigenesis, considering its epigenetic fluctuations in finding new biomarkers is of great importance. Modifications in DNA methylation pattern and also enrichment of methylated histone signs in the promoter regions of some certain genes like MUTYH, KLF4/6 and WNT1 in different signaling pathways could be a notable key contributors to the upregulation of tumor initiation in CRC. These epigenetic alterations could be employed as a practical diagnostic biomarkers for colorectal cancer. In this review, we will be discuss these fluctuations of MUTYH, KLF4/6 and WNT1 genes in CRC.https://biomedicine.edp-open.org/articles/bmdcn/full_html/2019/04/bmdcn2019090422/bmdcn2019090422.htmlepigeneticsfluctuationstumorigenesiscarcinogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Babaei Kosar Khaksar Roya Zeinali Tahereh Hemmati Hossein Bandegi Ahmadreza Samidoust Pirouz Ashoobi Mohammad Taghi Hashemian Hooman Delpasand Kourosh Talebinasab Fereshteh Naebi Hoora Mirpour Seyed Hossein Keymoradzadeh Arman Norollahi Seyedeh Elham |
spellingShingle |
Babaei Kosar Khaksar Roya Zeinali Tahereh Hemmati Hossein Bandegi Ahmadreza Samidoust Pirouz Ashoobi Mohammad Taghi Hashemian Hooman Delpasand Kourosh Talebinasab Fereshteh Naebi Hoora Mirpour Seyed Hossein Keymoradzadeh Arman Norollahi Seyedeh Elham Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer BioMedicine epigenetics fluctuations tumorigenesis carcinogenesis |
author_facet |
Babaei Kosar Khaksar Roya Zeinali Tahereh Hemmati Hossein Bandegi Ahmadreza Samidoust Pirouz Ashoobi Mohammad Taghi Hashemian Hooman Delpasand Kourosh Talebinasab Fereshteh Naebi Hoora Mirpour Seyed Hossein Keymoradzadeh Arman Norollahi Seyedeh Elham |
author_sort |
Babaei Kosar |
title |
Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
title_short |
Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
title_full |
Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
title_fullStr |
Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
title_full_unstemmed |
Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
title_sort |
epigenetic profiling of mutyh, klf6, wnt1 and klf4 genes in carcinogenesis and tumorigenesis of colorectal cancer |
publisher |
China Medical University |
series |
BioMedicine |
issn |
2211-8039 |
publishDate |
2019-12-01 |
description |
Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly if the gene was become silenced, leaving the mechanisms of methylation without any response. According to the methylation situation which has a strong eagerness to be highly altered on CpG islands in carcinogenesis and tumorigenesis, considering its epigenetic fluctuations in finding new biomarkers is of great importance. Modifications in DNA methylation pattern and also enrichment of methylated histone signs in the promoter regions of some certain genes like MUTYH, KLF4/6 and WNT1 in different signaling pathways could be a notable key contributors to the upregulation of tumor initiation in CRC. These epigenetic alterations could be employed as a practical diagnostic biomarkers for colorectal cancer. In this review, we will be discuss these fluctuations of MUTYH, KLF4/6 and WNT1 genes in CRC. |
topic |
epigenetics fluctuations tumorigenesis carcinogenesis |
url |
https://biomedicine.edp-open.org/articles/bmdcn/full_html/2019/04/bmdcn2019090422/bmdcn2019090422.html |
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