A structural model of flagellar filament switching across multiple bacterial species

Bacterial flagellar filaments are composed almost entirely of a single protein—flagellin—which can switch between different supercoiled states in a highly cooperative manner. Here the authors present near-atomic resolution cryo-EM structures of nine flagellar filaments, and begin to shed light on th...

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Main Authors:	Fengbin Wang, Andrew M. Burrage, Sandra Postel, Reece E. Clark, Albina Orlova, Eric J. Sundberg, Daniel B. Kearns, Edward H. Egelman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01075-5

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spelling	doaj-e14488ec74474b9e8d8b969e96834ad02021-05-11T07:49:11ZengNature Publishing GroupNature Communications2041-17232017-10-018111310.1038/s41467-017-01075-5A structural model of flagellar filament switching across multiple bacterial speciesFengbin Wang0Andrew M. Burrage1Sandra Postel2Reece E. Clark3Albina Orlova4Eric J. Sundberg5Daniel B. Kearns6Edward H. Egelman7Department of Biochemistry and Molecular Genetics, University of Virginia School of MedicineDepartment of Biology, Indiana UniversityInstitute of Human Virology and University of Maryland School of MedicineDepartment of Biology, Indiana UniversityDepartment of Biochemistry and Molecular Genetics, University of Virginia School of MedicineInstitute of Human Virology and University of Maryland School of MedicineDepartment of Biology, Indiana UniversityDepartment of Biochemistry and Molecular Genetics, University of Virginia School of MedicineBacterial flagellar filaments are composed almost entirely of a single protein—flagellin—which can switch between different supercoiled states in a highly cooperative manner. Here the authors present near-atomic resolution cryo-EM structures of nine flagellar filaments, and begin to shed light on the molecular basis of filament switching.https://doi.org/10.1038/s41467-017-01075-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fengbin Wang Andrew M. Burrage Sandra Postel Reece E. Clark Albina Orlova Eric J. Sundberg Daniel B. Kearns Edward H. Egelman
spellingShingle	Fengbin Wang Andrew M. Burrage Sandra Postel Reece E. Clark Albina Orlova Eric J. Sundberg Daniel B. Kearns Edward H. Egelman A structural model of flagellar filament switching across multiple bacterial species Nature Communications
author_facet	Fengbin Wang Andrew M. Burrage Sandra Postel Reece E. Clark Albina Orlova Eric J. Sundberg Daniel B. Kearns Edward H. Egelman
author_sort	Fengbin Wang
title	A structural model of flagellar filament switching across multiple bacterial species
title_short	A structural model of flagellar filament switching across multiple bacterial species
title_full	A structural model of flagellar filament switching across multiple bacterial species
title_fullStr	A structural model of flagellar filament switching across multiple bacterial species
title_full_unstemmed	A structural model of flagellar filament switching across multiple bacterial species
title_sort	structural model of flagellar filament switching across multiple bacterial species
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Bacterial flagellar filaments are composed almost entirely of a single protein—flagellin—which can switch between different supercoiled states in a highly cooperative manner. Here the authors present near-atomic resolution cryo-EM structures of nine flagellar filaments, and begin to shed light on the molecular basis of filament switching.
url	https://doi.org/10.1038/s41467-017-01075-5
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A structural model of flagellar filament switching across multiple bacterial species

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