Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Serum interleukin- (IL-) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum...
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doaj-e14727fae6f04b05872f3e5ac5d1bfdd2021-08-02T00:00:28ZengHindawi LimitedMediators of Inflammation1466-18612021-01-01202110.1155/2021/6668884Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated VasculitisTaejun Yoon0Sung Soo Ahn1Jung Yoo Pyo2Lucy Eunju Lee3Jason Jungsik Song4Yong-Beom Park5Sang-Won Lee6Department of Medical ScienceDivision of RheumatologyDivision of RheumatologyDivision of RheumatologyDivision of RheumatologyDivision of RheumatologyDivision of RheumatologySerum interleukin- (IL-) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum IL-27, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL-27 level for disease activity. This study included 77 AAV patients, and we collected clinical and laboratory data at blood sampling. Inflammation-related variables included white blood cell, neutrophil, lymphocyte and platelet counts, serum albumin, erythrocyte sedimentation rate, and C-reactive protein levels. Serum IL-27 and IL-18 levels were measured from stored sera using Human Magnetic Luminex® assay. High disease activity of AAV was defined as the highest tertile of Birmingham vasculitis activity score (BVAS) (≥11). The mean age of the enrolled patients was 59.9 years, and 38 (49.4%) were diagnosed as microscopic polyangiitis. In the multivariable analysis, serum albumin (β=−0.419) and serum IL-27 level (β=0.221) were significantly associated with BVAS. Furthermore, patients with renal manifestation exhibited higher serum IL-27 (mean 308.7 pg/mL vs. 105.8 pg/mL) and IL-18 levels (mean 376.7 pg/mL vs. 270.4 pg/mL) than those without. On applying the optimal cut-off of serum IL-27 level for predicting high activity, AAV patients with serum IL−27 level≥300.8 pg/mL had a significantly higher risk for having high disease activity than those with serum IL−27 level<300.8 pg/mL (relative risk 3.380, 95% confidence interval 1.223, 9.345, P=0.016). These results suggest that serum IL-27 level is associated with the cross-sectional activity and the presence of renal manifestation and could be used to predict high disease activity in patients with AAV.http://dx.doi.org/10.1155/2021/6668884 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taejun Yoon Sung Soo Ahn Jung Yoo Pyo Lucy Eunju Lee Jason Jungsik Song Yong-Beom Park Sang-Won Lee |
spellingShingle |
Taejun Yoon Sung Soo Ahn Jung Yoo Pyo Lucy Eunju Lee Jason Jungsik Song Yong-Beom Park Sang-Won Lee Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Mediators of Inflammation |
author_facet |
Taejun Yoon Sung Soo Ahn Jung Yoo Pyo Lucy Eunju Lee Jason Jungsik Song Yong-Beom Park Sang-Won Lee |
author_sort |
Taejun Yoon |
title |
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis |
title_short |
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis |
title_full |
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis |
title_fullStr |
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis |
title_full_unstemmed |
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis |
title_sort |
predictive ability of serum il-27 level for assessing activity of antineutrophil cytoplasmic antibody-associated vasculitis |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
1466-1861 |
publishDate |
2021-01-01 |
description |
Serum interleukin- (IL-) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum IL-27, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL-27 level for disease activity. This study included 77 AAV patients, and we collected clinical and laboratory data at blood sampling. Inflammation-related variables included white blood cell, neutrophil, lymphocyte and platelet counts, serum albumin, erythrocyte sedimentation rate, and C-reactive protein levels. Serum IL-27 and IL-18 levels were measured from stored sera using Human Magnetic Luminex® assay. High disease activity of AAV was defined as the highest tertile of Birmingham vasculitis activity score (BVAS) (≥11). The mean age of the enrolled patients was 59.9 years, and 38 (49.4%) were diagnosed as microscopic polyangiitis. In the multivariable analysis, serum albumin (β=−0.419) and serum IL-27 level (β=0.221) were significantly associated with BVAS. Furthermore, patients with renal manifestation exhibited higher serum IL-27 (mean 308.7 pg/mL vs. 105.8 pg/mL) and IL-18 levels (mean 376.7 pg/mL vs. 270.4 pg/mL) than those without. On applying the optimal cut-off of serum IL-27 level for predicting high activity, AAV patients with serum IL−27 level≥300.8 pg/mL had a significantly higher risk for having high disease activity than those with serum IL−27 level<300.8 pg/mL (relative risk 3.380, 95% confidence interval 1.223, 9.345, P=0.016). These results suggest that serum IL-27 level is associated with the cross-sectional activity and the presence of renal manifestation and could be used to predict high disease activity in patients with AAV. |
url |
http://dx.doi.org/10.1155/2021/6668884 |
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