Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly
The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the plasma membrane. This network is frequently perturbed by positive-strand RNA viruses utilizing the ER to create membrano...
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doaj-e1510743a6fb41e0aea85ec9c05424812020-11-24T23:56:46ZengMDPI AGViruses1999-49152016-06-018616010.3390/v8060160v8060160Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and AssemblyInés Romero-Brey0Ralf Bartenschlager1Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, Heidelberg 69120, GermanyDepartment of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, Heidelberg 69120, GermanyThe endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the plasma membrane. This network is frequently perturbed by positive-strand RNA viruses utilizing the ER to create membranous replication factories (RFs), where amplification of their genomes occurs. In addition, many enveloped viruses assemble progeny virions in association with ER membranes, and viruses replicating in the nucleus need to overcome the NE barrier, requiring transient changes of the NE morphology. This review first summarizes some key aspects of ER morphology and then focuses on the exploitation of the ER by viruses for the sake of promoting the different steps of their replication cycles.http://www.mdpi.com/1999-4915/8/6/160intracellular organellescell membranesmembrane rearrangementsnuclear envelopeperipheral endoplasmic reticulum (ER)virus-host interactionsviral replicationvirion assemblyvesicleselectron microscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Inés Romero-Brey Ralf Bartenschlager |
spellingShingle |
Inés Romero-Brey Ralf Bartenschlager Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly Viruses intracellular organelles cell membranes membrane rearrangements nuclear envelope peripheral endoplasmic reticulum (ER) virus-host interactions viral replication virion assembly vesicles electron microscopy |
author_facet |
Inés Romero-Brey Ralf Bartenschlager |
author_sort |
Inés Romero-Brey |
title |
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly |
title_short |
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly |
title_full |
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly |
title_fullStr |
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly |
title_full_unstemmed |
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly |
title_sort |
endoplasmic reticulum: the favorite intracellular niche for viral replication and assembly |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2016-06-01 |
description |
The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the plasma membrane. This network is frequently perturbed by positive-strand RNA viruses utilizing the ER to create membranous replication factories (RFs), where amplification of their genomes occurs. In addition, many enveloped viruses assemble progeny virions in association with ER membranes, and viruses replicating in the nucleus need to overcome the NE barrier, requiring transient changes of the NE morphology. This review first summarizes some key aspects of ER morphology and then focuses on the exploitation of the ER by viruses for the sake of promoting the different steps of their replication cycles. |
topic |
intracellular organelles cell membranes membrane rearrangements nuclear envelope peripheral endoplasmic reticulum (ER) virus-host interactions viral replication virion assembly vesicles electron microscopy |
url |
http://www.mdpi.com/1999-4915/8/6/160 |
work_keys_str_mv |
AT inesromerobrey endoplasmicreticulumthefavoriteintracellularnicheforviralreplicationandassembly AT ralfbartenschlager endoplasmicreticulumthefavoriteintracellularnicheforviralreplicationandassembly |
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