Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses
Abstract Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversity Covering (DiCo) protein sequences were designed a...
Main Authors: | Edmond J. Remarque, Bart W. Faber, Roberto Rodriguez Garcia, Herman Oostermeijer, Sodiomon B. Sirima, Issa Nebie Ouedraogo, Leila Kara, Odile Launay, Sophie Houard, Odile Leroy, Clemens H. M. Kocken |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-021-00319-2 |
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