Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale
Abstract Aims The purpose of this study were to identify the usefulness of screening for PFO using agitated saline echocardiography (ASE) and characteristics and prognosis of patients with suggestive of patent foramen ovale (PFO). Methods Three hundred three patients (mean age, 53 ± 9 years; 199 [66...
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doaj-e156c61cda8e49d8b2d9a43408726a972021-06-06T11:11:29ZengBMCCardiovascular Ultrasound1476-71202021-06-0119111010.1186/s12947-021-00255-0Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovaleJaehuk Choi0Min-Kyung Kang1Jin-Sun Jun2Dong Geum Shin3Donghoon Han4Seonghoon Choi5Jung Rae Cho6Namho Lee7Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Neurology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterDivision of Cardiology, Kangnam Sacred Heart Hospital, Hallym University Medical CenterAbstract Aims The purpose of this study were to identify the usefulness of screening for PFO using agitated saline echocardiography (ASE) and characteristics and prognosis of patients with suggestive of patent foramen ovale (PFO). Methods Three hundred three patients (mean age, 53 ± 9 years; 199 [66%] men) admitted with acute stroke or suspicion of stroke were included. Patients were classified into those with and without right-to-left shunt (RLS) according to the ASE results (positive ASE [n = 92] vs. negative ASE [n = 211]). Fifty-one out of ninety-two patients with positive ASE and twenty-one out of two hundred eleven patients with negative ASE underwent TEE with ASE to confirm PFO. Results Ninety-two were positive for ASE and thirty-six of the fifty-one patients who underwent TEE were confirmed as having PFO. Of the patients with RLS grade 1, 50% were diagnosed with PFO and all patients with RLS grade ≥ 2 were diagnosed with PFO. All patients with negative ASE had no PFO (sensitivity of 100% and specificity of 58%). Patients with positive ASE were younger, had a lower body mass, and a lower prevalence of hypertension. The positive ASE patients had a higher mean Sʹ velocity and better diastolic function. Four of ninety-one patients with positive ASE and thirteen of one hundred seventy-seven showed recurrence of stroke and suspicion of stroke. Conclusion Transthoracic ASE is a good method to screen for PFO. Patients with suggestive of PFO had lower risk factors, less atherosclerosis, and better cardiac performance.https://doi.org/10.1186/s12947-021-00255-0Cryptogenic strokePatent foramen ovaleAgitated saline echocardiography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jaehuk Choi Min-Kyung Kang Jin-Sun Jun Dong Geum Shin Donghoon Han Seonghoon Choi Jung Rae Cho Namho Lee |
spellingShingle |
Jaehuk Choi Min-Kyung Kang Jin-Sun Jun Dong Geum Shin Donghoon Han Seonghoon Choi Jung Rae Cho Namho Lee Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale Cardiovascular Ultrasound Cryptogenic stroke Patent foramen ovale Agitated saline echocardiography |
author_facet |
Jaehuk Choi Min-Kyung Kang Jin-Sun Jun Dong Geum Shin Donghoon Han Seonghoon Choi Jung Rae Cho Namho Lee |
author_sort |
Jaehuk Choi |
title |
Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
title_short |
Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
title_full |
Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
title_fullStr |
Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
title_full_unstemmed |
Characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
title_sort |
characteristics and prognosis of patients with cryptogenic stroke and suggestive of patent foramen ovale |
publisher |
BMC |
series |
Cardiovascular Ultrasound |
issn |
1476-7120 |
publishDate |
2021-06-01 |
description |
Abstract Aims The purpose of this study were to identify the usefulness of screening for PFO using agitated saline echocardiography (ASE) and characteristics and prognosis of patients with suggestive of patent foramen ovale (PFO). Methods Three hundred three patients (mean age, 53 ± 9 years; 199 [66%] men) admitted with acute stroke or suspicion of stroke were included. Patients were classified into those with and without right-to-left shunt (RLS) according to the ASE results (positive ASE [n = 92] vs. negative ASE [n = 211]). Fifty-one out of ninety-two patients with positive ASE and twenty-one out of two hundred eleven patients with negative ASE underwent TEE with ASE to confirm PFO. Results Ninety-two were positive for ASE and thirty-six of the fifty-one patients who underwent TEE were confirmed as having PFO. Of the patients with RLS grade 1, 50% were diagnosed with PFO and all patients with RLS grade ≥ 2 were diagnosed with PFO. All patients with negative ASE had no PFO (sensitivity of 100% and specificity of 58%). Patients with positive ASE were younger, had a lower body mass, and a lower prevalence of hypertension. The positive ASE patients had a higher mean Sʹ velocity and better diastolic function. Four of ninety-one patients with positive ASE and thirteen of one hundred seventy-seven showed recurrence of stroke and suspicion of stroke. Conclusion Transthoracic ASE is a good method to screen for PFO. Patients with suggestive of PFO had lower risk factors, less atherosclerosis, and better cardiac performance. |
topic |
Cryptogenic stroke Patent foramen ovale Agitated saline echocardiography |
url |
https://doi.org/10.1186/s12947-021-00255-0 |
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