Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is assoc...
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doaj-e15bc056634b47188695294f8eadf75d2020-11-25T01:09:43ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212017-01-01Volume 1320120430989Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image studyIfteni PTeodorescu AMoga MAPascu AMMiclaus RSPetru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is associated with periodic symptom exacerbations, leading to functional impairment, and increased risk of suicide. Although clozapine has never been approved for the treatment of BD, it is occasionally used in severe mania. The aim of the study is to evaluate the risks and benefits of switching clozapine in remitted BD patients. This is an observational, mirror image study of 62 consecutive remitted BD outpatients treated with clozapine. Twenty-five patients were switched to another antipsychotic following a change in a drug reimbursement rule, while 37 continued on clozapine. The mean time in remission was shorter for the switched group (9.2±4 months vs 13±6 months, P=0.018), and the number of patients who relapsed was larger (n=21 vs n=8, P<0.0001). The results suggest that switching from clozapine to another antipsychotic may increase the risk of relapses in remitted patients with BD. Keywords: clozapine, bipolar disorder, relapse, switch, costhttps://www.dovepress.com/switching-bipolar-disorder-patients-treated-with-clozapine-to-another--peer-reviewed-article-NDTclozapinebipolar disorderrelapseswitchcost |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS |
spellingShingle |
Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study Neuropsychiatric Disease and Treatment clozapine bipolar disorder relapse switch cost |
author_facet |
Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS |
author_sort |
Ifteni P |
title |
Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
title_short |
Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
title_full |
Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
title_fullStr |
Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
title_full_unstemmed |
Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
title_sort |
switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study |
publisher |
Dove Medical Press |
series |
Neuropsychiatric Disease and Treatment |
issn |
1178-2021 |
publishDate |
2017-01-01 |
description |
Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is associated with periodic symptom exacerbations, leading to functional impairment, and increased risk of suicide. Although clozapine has never been approved for the treatment of BD, it is occasionally used in severe mania. The aim of the study is to evaluate the risks and benefits of switching clozapine in remitted BD patients. This is an observational, mirror image study of 62 consecutive remitted BD outpatients treated with clozapine. Twenty-five patients were switched to another antipsychotic following a change in a drug reimbursement rule, while 37 continued on clozapine. The mean time in remission was shorter for the switched group (9.2±4 months vs 13±6 months, P=0.018), and the number of patients who relapsed was larger (n=21 vs n=8, P<0.0001). The results suggest that switching from clozapine to another antipsychotic may increase the risk of relapses in remitted patients with BD. Keywords: clozapine, bipolar disorder, relapse, switch, cost |
topic |
clozapine bipolar disorder relapse switch cost |
url |
https://www.dovepress.com/switching-bipolar-disorder-patients-treated-with-clozapine-to-another--peer-reviewed-article-NDT |
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