Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.

Bibliographic Details
Main Authors:	Shannon L. Wolfman, Daniel F. Gill, Fili Bogdanic, Katie Long, Ream Al-Hasani, Jordan G. McCall, Michael R. Bruchas, Daniel S. McGehee
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04654-2

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spelling	doaj-e15d944c114d4cb58850d8356381d6602021-05-11T10:05:15ZengNature Publishing GroupNature Communications2041-17232018-07-019111110.1038/s41467-018-04654-2Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentumShannon L. Wolfman0Daniel F. Gill1Fili Bogdanic2Katie Long3Ream Al-Hasani4Jordan G. McCall5Michael R. Bruchas6Daniel S. McGehee7Committee on Neurobiology, University of ChicagoCommittee on Neurobiology, University of ChicagoDepartment of Anesthesia & Critical Care, University of ChicagoInterdisciplinary Scientist Training Program, University of ChicagoSt. Louis College of Pharmacy, Center for Clinical Pharmacology and Division of Basic Research of the Department of Anesthesiology, Washington University School of MedicineSt. Louis College of Pharmacy, Center for Clinical Pharmacology and Division of Basic Research of the Department of Anesthesiology, Washington University School of MedicineDivision of Basic Research, Department of Anesthesiology, Washington University Pain CenterCommittee on Neurobiology, University of ChicagoDespite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.https://doi.org/10.1038/s41467-018-04654-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
spellingShingle	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum Nature Communications
author_facet	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
author_sort	Shannon L. Wolfman
title	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_short	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_fullStr	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full_unstemmed	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_sort	nicotine aversion is mediated by gabaergic interpeduncular nucleus inputs to laterodorsal tegmentum
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.
url	https://doi.org/10.1038/s41467-018-04654-2
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Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

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