Structure of the homodimeric androgen receptor ligand-binding domain
The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activityin vivo.
Bibliographic Details
| Main Authors: |
Marta Nadal,
Stefan Prekovic,
Nerea Gallastegui,
Christine Helsen,
Montserrat Abella,
Karolina Zielinska,
Marina Gay,
Marta Vilaseca,
Marta Taulès,
Adriaan B. Houtsmuller,
Martin E. van Royen,
Frank Claessens,
Pablo Fuentes-Prior,
Eva Estébanez-Perpiñá |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14388
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