Research on the serum levels of TNF-α, IFN-γ and MCP-1 in patients with Behcet's disease

• Main Authors: Yong-Gang Yuan, Na Liang, Sheng-Sheng Ma, Dong-Jian Zheng
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-04-01
• Series: Guoji Yanke Zazhi
• Subjects: Behcet's disease; cytokine; TNF-α; IFN-γ; MCP-1
• Online Access: http://www.ies.net.cn/cn_publish/2014/4/201404063.pdf
• ISSN: 1672-5123; 1672-5123

AIM: To study the serum levels of TNF-α, IFN-γ and MCP-1 in patients with Behcet's disease(BD).<p>METHOS: Twenty-five patients with BD as study group and 30 normal volunteers as control group were inclued in the study. Serum levels of TNF-α, IFN-γ and MCP-1 were measured. <p>RESULTS: Serum levels of TNF-α, IFN-γ and MCP-1 were significant higher in active BD patients than in normal controls.<p>CONCLUSION: Our results suggest that serum levels of TNF-α, IFN-γ and MCP-1 abnormally increased in active BD paiteins. The higher expression may play a role in the pathogenesis of BD.