The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats

• Main Authors: Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Triantafyllou Aggeliki, Zografos George, Papalois Apostolos
• Format: Article
• Language: English
• Published: Sciendo 2016-09-01
• Series: Serbian Journal of Experimental and Clinical Research
• Subjects: ischaemia; u-74389g; uric acid; reperfusion
• Online Access: https://doi.org/10.1515/sjecr-2016-0035
• ISSN: 1820-8665; 2335-075X

This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours.