The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats
This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used...
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doaj-e176ea3b66e64690b220fe76141631242021-09-05T14:00:38ZengSciendoSerbian Journal of Experimental and Clinical Research 1820-86652335-075X2016-09-0117324725010.1515/sjecr-2016-0035sjecr-2016-0035The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in RatsTsompos Constantinos0Panoulis Constantinos1Toutouzas Konstantinos2Triantafyllou Aggeliki3Zografos George4Papalois Apostolos5Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, GreeceDepartment of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, GreeceDepartment of Surgery, Ippokrateion General Hospital, Athens University, Attiki, GreeceDepartment of Biologic Chemistry, Athens University, Attiki, GreeceDepartment of Surgery, Ippokrateion General Hospital, Athens University, Attiki, GreeceExperimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki, GreeceThis experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours.https://doi.org/10.1515/sjecr-2016-0035ischaemiau-74389guric acidreperfusion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tsompos Constantinos Panoulis Constantinos Toutouzas Konstantinos Triantafyllou Aggeliki Zografos George Papalois Apostolos |
spellingShingle |
Tsompos Constantinos Panoulis Constantinos Toutouzas Konstantinos Triantafyllou Aggeliki Zografos George Papalois Apostolos The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats Serbian Journal of Experimental and Clinical Research ischaemia u-74389g uric acid reperfusion |
author_facet |
Tsompos Constantinos Panoulis Constantinos Toutouzas Konstantinos Triantafyllou Aggeliki Zografos George Papalois Apostolos |
author_sort |
Tsompos Constantinos |
title |
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats |
title_short |
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats |
title_full |
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats |
title_fullStr |
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats |
title_full_unstemmed |
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats |
title_sort |
effect of the antioxidant drug u-74389g on uric acid levels during ischemia reperfusion injury in rats |
publisher |
Sciendo |
series |
Serbian Journal of Experimental and Clinical Research |
issn |
1820-8665 2335-075X |
publishDate |
2016-09-01 |
description |
This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours. |
topic |
ischaemia u-74389g uric acid reperfusion |
url |
https://doi.org/10.1515/sjecr-2016-0035 |
work_keys_str_mv |
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