Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review
The management of advanced gastric cancer has improved over the past decade. There is more evidence to support the efficacy of systemic treatment in refractory gastric cancer beyond second-line treatment. Important randomized controlled trials of chemotherapies, targeted agents and immunotherapies h...
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2019-06-01
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Series: | Therapeutic Advances in Medical Oncology |
Online Access: | https://doi.org/10.1177/1758835919859990 |
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doaj-e17bb721ef2a4579813cfbcc70d784fe2020-11-25T03:42:55ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592019-06-011110.1177/1758835919859990Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive reviewWing-lok ChanKa-on LamTsz-him SoVictor Ho-fun LeeLai-wan Dora KwongThe management of advanced gastric cancer has improved over the past decade. There is more evidence to support the efficacy of systemic treatment in refractory gastric cancer beyond second-line treatment. Important randomized controlled trials of chemotherapies, targeted agents and immunotherapies have been reported. With the development of these novel therapies, clinicians can better individualize treatment for patients beyond progression on second-line therapy. However, there is no guideline on third-line therapy available for clinicians. This review discussed the efficacy and safety data from the pivotal trials of the agents proven to be effective in third-line settings, including the quality of study design, level of evidence and subgroup analysis, and how the data can help to guide clinicians on selecting the most appropriate third-line therapy for their patients.https://doi.org/10.1177/1758835919859990 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wing-lok Chan Ka-on Lam Tsz-him So Victor Ho-fun Lee Lai-wan Dora Kwong |
spellingShingle |
Wing-lok Chan Ka-on Lam Tsz-him So Victor Ho-fun Lee Lai-wan Dora Kwong Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review Therapeutic Advances in Medical Oncology |
author_facet |
Wing-lok Chan Ka-on Lam Tsz-him So Victor Ho-fun Lee Lai-wan Dora Kwong |
author_sort |
Wing-lok Chan |
title |
Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
title_short |
Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
title_full |
Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
title_fullStr |
Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
title_full_unstemmed |
Third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
title_sort |
third-line systemic treatment in advanced/metastatic gastric cancer: a comprehensive review |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Medical Oncology |
issn |
1758-8359 |
publishDate |
2019-06-01 |
description |
The management of advanced gastric cancer has improved over the past decade. There is more evidence to support the efficacy of systemic treatment in refractory gastric cancer beyond second-line treatment. Important randomized controlled trials of chemotherapies, targeted agents and immunotherapies have been reported. With the development of these novel therapies, clinicians can better individualize treatment for patients beyond progression on second-line therapy. However, there is no guideline on third-line therapy available for clinicians. This review discussed the efficacy and safety data from the pivotal trials of the agents proven to be effective in third-line settings, including the quality of study design, level of evidence and subgroup analysis, and how the data can help to guide clinicians on selecting the most appropriate third-line therapy for their patients. |
url |
https://doi.org/10.1177/1758835919859990 |
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1724522540002443264 |