PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity

PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity

Human carbonic anhydrase IX (CAIX), a unique member of the α carbonic anhydrase family, is a transmembrane glycoprotein with high enzymatic activity by which CAIX contributes to tumorigenesis through pH regulation. Due to its aberrant expression, CAIX is considered to be a marker of tumor hypoxia an...

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Bibliographic Details
Main Authors: Veronika Simko, Petra Belvoncikova, Lucia Csaderova, Martina Labudova, Katarina Grossmannova, Miriam Zatovicova, Ivana Kajanova, Ludovit Skultety, Monika Barathova, Jaromir Pastorek
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
carbonic anhydrase IX (CAIX)
pH regulation
intracellular binding partner
protein-L-isoaspartyl methyltransferase (PIMT)
hypoxia
cancer
Online Access:https://www.mdpi.com/1422-0067/21/22/8545

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