Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications
Abstract Background We compared cardiovascular magnetic resonance segmental native T1 against T2* values for the detection of myocardial iron overload (MIO) in thalassaemia major and we evaluated the clinical correlates of native T1 measurements. Methods We considered 146 patients (87 females, 38.7 ...
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doaj-e1869f96275a4119addbaa3224775d742021-06-20T11:44:50ZengBMCJournal of Cardiovascular Magnetic Resonance1532-429X2021-06-0123111010.1186/s12968-021-00765-wMyocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complicationsAntonella Meloni0Nicola Martini1Vincenzo Positano2Antonio De Luca3Laura Pistoia4Sara Sbragi5Anna Spasiano6Tommaso Casini7Pier Paolo Bitti8Massimo Allò9Paola Maria Grazia Sanna10Raffaele De Caterina11Gianfranco Sinagra12Alessia Pepe13Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione ToscanaMagnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione ToscanaMagnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione ToscanaCardiovascular Department, University of TriesteMagnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione ToscanaCardiovascular Division, University of PisaUnità Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale “A. Cardarelli”Centro Talassemie ed Emoglobinopatie, Ospedale “Meyer”Servizio Immunoematologia e Medicina Trasfusionale, Dipartimento dei Servizi, Presidio Ospedaliero “San Francesco” ASL NuoroEmatologia Microcitemia, Ospedale San Giovanni di Dio, ASP CrotoneServizio Trasfusionale Aziendale, Azienda Ospedaliero-Universitaria di SassariCardiovascular Division, University of PisaCardiovascular Department, University of TriesteMagnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione ToscanaAbstract Background We compared cardiovascular magnetic resonance segmental native T1 against T2* values for the detection of myocardial iron overload (MIO) in thalassaemia major and we evaluated the clinical correlates of native T1 measurements. Methods We considered 146 patients (87 females, 38.7 ± 11.1 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassaemia Network. T1 and T2* values were obtained in the 16 left ventricular (LV) segments. LV function parameters were quantified by cine images. Post-contrast late gadolinium enhancement (LGE) and T1 images were acquired. Results 64.1% of segments had normal T2* and T1 values while 10.1% had pathologic T2* and T1 values. In 526 (23.0%) segments, there was a pathologic T1 and a normal T2* value while 65 (2.8%) segments had a pathologic T2* value but a normal T1 and an extracellular volume (ECV) ≥ 25% was detected in 16 of 19 segments where ECV was quantified. Global native T1 was independent from gender or LV function but decreased with increasing age. Patients with replacement myocardial fibrosis had significantly lower native global T1. Patients with cardiac complications had significantly lower native global T1. Conclusions The combined use of both segmental native T1 and T2* values could improve the sensitivity for detecting MIO. Native T1 is associated with cardiac complications in thalassaemia major.https://doi.org/10.1186/s12968-021-00765-wIron overloadThalassaemia majorMagnetic resonance imagingCardiovascular diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonella Meloni Nicola Martini Vincenzo Positano Antonio De Luca Laura Pistoia Sara Sbragi Anna Spasiano Tommaso Casini Pier Paolo Bitti Massimo Allò Paola Maria Grazia Sanna Raffaele De Caterina Gianfranco Sinagra Alessia Pepe |
spellingShingle |
Antonella Meloni Nicola Martini Vincenzo Positano Antonio De Luca Laura Pistoia Sara Sbragi Anna Spasiano Tommaso Casini Pier Paolo Bitti Massimo Allò Paola Maria Grazia Sanna Raffaele De Caterina Gianfranco Sinagra Alessia Pepe Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications Journal of Cardiovascular Magnetic Resonance Iron overload Thalassaemia major Magnetic resonance imaging Cardiovascular diseases |
author_facet |
Antonella Meloni Nicola Martini Vincenzo Positano Antonio De Luca Laura Pistoia Sara Sbragi Anna Spasiano Tommaso Casini Pier Paolo Bitti Massimo Allò Paola Maria Grazia Sanna Raffaele De Caterina Gianfranco Sinagra Alessia Pepe |
author_sort |
Antonella Meloni |
title |
Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications |
title_short |
Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications |
title_full |
Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications |
title_fullStr |
Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications |
title_full_unstemmed |
Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications |
title_sort |
myocardial iron overload by cardiovascular magnetic resonance native segmental t1 mapping: a sensitive approach that correlates with cardiac complications |
publisher |
BMC |
series |
Journal of Cardiovascular Magnetic Resonance |
issn |
1532-429X |
publishDate |
2021-06-01 |
description |
Abstract Background We compared cardiovascular magnetic resonance segmental native T1 against T2* values for the detection of myocardial iron overload (MIO) in thalassaemia major and we evaluated the clinical correlates of native T1 measurements. Methods We considered 146 patients (87 females, 38.7 ± 11.1 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassaemia Network. T1 and T2* values were obtained in the 16 left ventricular (LV) segments. LV function parameters were quantified by cine images. Post-contrast late gadolinium enhancement (LGE) and T1 images were acquired. Results 64.1% of segments had normal T2* and T1 values while 10.1% had pathologic T2* and T1 values. In 526 (23.0%) segments, there was a pathologic T1 and a normal T2* value while 65 (2.8%) segments had a pathologic T2* value but a normal T1 and an extracellular volume (ECV) ≥ 25% was detected in 16 of 19 segments where ECV was quantified. Global native T1 was independent from gender or LV function but decreased with increasing age. Patients with replacement myocardial fibrosis had significantly lower native global T1. Patients with cardiac complications had significantly lower native global T1. Conclusions The combined use of both segmental native T1 and T2* values could improve the sensitivity for detecting MIO. Native T1 is associated with cardiac complications in thalassaemia major. |
topic |
Iron overload Thalassaemia major Magnetic resonance imaging Cardiovascular diseases |
url |
https://doi.org/10.1186/s12968-021-00765-w |
work_keys_str_mv |
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