| Summary: | The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the detector have been fabricated based on silicon-on-insulator nanoribbon structures (SOI nanoribbon chip), using a complementary metal-oxide-semiconductor (CMOS)-compatible technology—by means of gas-phase etching and standard optical photolithography. The surface of the SOI nanoribbon chip contains a matrix of 10 nanoribbon (NR) sensor elements. SOI nanoribbon chips of n-type conductance have been used for this study. For biospecific detection of target particles, antibodies against influenza virus have been covalently immobilized onto NRs. Influenza A virus detection was performed by real-time registration of the source-drain current through the NRs. The detection of the target viral particles was carried out in buffer solutions at the target particles concentration within the range from 10<sup>7</sup> to 10<sup>3</sup> viral particles per milliliter (VP/mL). The lowest detectable concentration of the target viral particles was 6 × 10<sup>−16</sup> M (corresponding to 10<sup>4</sup> VP/mL). The use of solutions containing ~10<sup>9</sup> to 10<sup>10</sup> VP/mL resulted in saturation of the sensor surface with the target virions. In the saturation mode, detection was impossible.
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