Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).

Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance...

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Main Authors:	Benjamin Bruno Policicchio, Paola Sette, Cuiling Xu, George Haret-Richter, Tammy Dunsmore, Ivona Pandrea, Ruy M Ribeiro, Cristian Apetrei
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5821307?pdf=render

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spelling	doaj-e187f374441e4f0690f7547de5f8f9d32020-11-24T22:03:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019090810.1371/journal.pone.0190908Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).Benjamin Bruno PolicicchioPaola SetteCuiling XuGeorge Haret-RichterTammy DunsmoreIvona PandreaRuy M RibeiroCristian ApetreiTwo SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation.http://europepmc.org/articles/PMC5821307?pdf=render
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Benjamin Bruno Policicchio Paola Sette Cuiling Xu George Haret-Richter Tammy Dunsmore Ivona Pandrea Ruy M Ribeiro Cristian Apetrei
spellingShingle	Benjamin Bruno Policicchio Paola Sette Cuiling Xu George Haret-Richter Tammy Dunsmore Ivona Pandrea Ruy M Ribeiro Cristian Apetrei Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART). PLoS ONE
author_facet	Benjamin Bruno Policicchio Paola Sette Cuiling Xu George Haret-Richter Tammy Dunsmore Ivona Pandrea Ruy M Ribeiro Cristian Apetrei
author_sort	Benjamin Bruno Policicchio
title	Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
title_short	Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
title_full	Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
title_fullStr	Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
title_full_unstemmed	Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
title_sort	emergence of resistance mutations in simian immunodeficiency virus (siv)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (art).
publisher	Public Library of Science (PLoS)
series	PLoS ONE
issn	1932-6203
publishDate	2018-01-01
description	Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation.
url	http://europepmc.org/articles/PMC5821307?pdf=render
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Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).

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