Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait
Abstract Background The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of...
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doaj-e18e1b33d94c440fa3916c780d9e55242020-12-06T12:19:45ZengBMCBMC Pregnancy and Childbirth1471-23932020-12-012011910.1186/s12884-020-03461-2Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in KuwaitAmal Ayed0Alia Embaireeg1Asmaa Benawadh2Wadha Al-Fouzan3Majdeda Hammoud4Monif Al-Hathal5Abeer Alzaydai6Ashraf Ahmad7Mariam Ayed8Obstetrics and Gynecology Department, Farwaniya HospitalPaediatric Department, Farwaniya HospitalObstetrics and Gynecology Department, Farwaniya HospitalDepartment of Microbiology, Faculty of Medicine, Kuwait UniversityPaediatrics Department, Faculty of Medicine, Kuwait UniversityNeonatal Department, Maternity HospitalObstetrics and Gynaecology Department, Al-Adan HospitalObstetrics and Gynecology Department, Farwaniya HospitalNeonatal Department, Farwaniya HospitalAbstract Background The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of pregnancy-related complications. The aim of the study is to describe the maternal and neonatal clinical characteristics and outcome of pregnancies with SARS-CoV-2 infection. Methods In this retrospective national-based study, we analyzed the medical records of all pregnant women infected with SARS-CoV-2 and their neonates who were admitted to New-Jahra Hospital (NJH), Kuwait, between March 15th 2020 and May 31st 2020. During the study period and as part of the public health measures, a total of 185 pregnant women infected with SARS-CoV-2, regardless of symptoms, were hospitalized at NJH, and were included. Maternal and neonatal clinical manifestations, laboratory tests and treatments were collected. The outcomes of pregnancies included miscarriage, intrauterine fetal death (IUFD), preterm birth and live birth were assessed until the end date of the outcomes follow-up (November 10th 2020). Results A total of 185 pregnant women infected with SARS-CoV-2 were enrolled with a median age of 31 years (interquartile range, IQR: 27.5–34), and median gestational age at diagnosis of SARS-CoV2 infection was 29 weeks (IQR: 18–34). The majority (88%) of these women had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). At the time of the analysis, out of the 185, 3 (1.6%) of the pregnant women had a miscarriage, 1 (0.54%) had IUFD which was not related to COVID-19, 16 (8.6%) had ongoing pregnancies and 165 (89%) had a live birth. Only 2 (1.1%) of these women developed severe pneumonia and required intensive care. A total of 167 neonates with two sets of twins were born with median gestational age at birth was 38 (IQR: 36–39) weeks. Most of the neonates were asymptomatic, and only 2 of them tested positive on day 5 by nasopharyngeal swab testing. Conclusions In this national-based study, most of the pregnant women infected with SARS-CoV-2 showed mild symptoms. Although mother-to-child vertical transmission of SARS-CoV-2 is possible, COVID-19 infection during pregnancy may not lead to unfavorable maternal and neonatal outcomes.https://doi.org/10.1186/s12884-020-03461-2SARS-CoV-2COVID-19Pregnant womenNeonatesClinical features |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amal Ayed Alia Embaireeg Asmaa Benawadh Wadha Al-Fouzan Majdeda Hammoud Monif Al-Hathal Abeer Alzaydai Ashraf Ahmad Mariam Ayed |
spellingShingle |
Amal Ayed Alia Embaireeg Asmaa Benawadh Wadha Al-Fouzan Majdeda Hammoud Monif Al-Hathal Abeer Alzaydai Ashraf Ahmad Mariam Ayed Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait BMC Pregnancy and Childbirth SARS-CoV-2 COVID-19 Pregnant women Neonates Clinical features |
author_facet |
Amal Ayed Alia Embaireeg Asmaa Benawadh Wadha Al-Fouzan Majdeda Hammoud Monif Al-Hathal Abeer Alzaydai Ashraf Ahmad Mariam Ayed |
author_sort |
Amal Ayed |
title |
Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait |
title_short |
Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait |
title_full |
Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait |
title_fullStr |
Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait |
title_full_unstemmed |
Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait |
title_sort |
maternal and perinatal characteristics and outcomes of pregnancies complicated with covid-19 in kuwait |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2020-12-01 |
description |
Abstract Background The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of pregnancy-related complications. The aim of the study is to describe the maternal and neonatal clinical characteristics and outcome of pregnancies with SARS-CoV-2 infection. Methods In this retrospective national-based study, we analyzed the medical records of all pregnant women infected with SARS-CoV-2 and their neonates who were admitted to New-Jahra Hospital (NJH), Kuwait, between March 15th 2020 and May 31st 2020. During the study period and as part of the public health measures, a total of 185 pregnant women infected with SARS-CoV-2, regardless of symptoms, were hospitalized at NJH, and were included. Maternal and neonatal clinical manifestations, laboratory tests and treatments were collected. The outcomes of pregnancies included miscarriage, intrauterine fetal death (IUFD), preterm birth and live birth were assessed until the end date of the outcomes follow-up (November 10th 2020). Results A total of 185 pregnant women infected with SARS-CoV-2 were enrolled with a median age of 31 years (interquartile range, IQR: 27.5–34), and median gestational age at diagnosis of SARS-CoV2 infection was 29 weeks (IQR: 18–34). The majority (88%) of these women had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). At the time of the analysis, out of the 185, 3 (1.6%) of the pregnant women had a miscarriage, 1 (0.54%) had IUFD which was not related to COVID-19, 16 (8.6%) had ongoing pregnancies and 165 (89%) had a live birth. Only 2 (1.1%) of these women developed severe pneumonia and required intensive care. A total of 167 neonates with two sets of twins were born with median gestational age at birth was 38 (IQR: 36–39) weeks. Most of the neonates were asymptomatic, and only 2 of them tested positive on day 5 by nasopharyngeal swab testing. Conclusions In this national-based study, most of the pregnant women infected with SARS-CoV-2 showed mild symptoms. Although mother-to-child vertical transmission of SARS-CoV-2 is possible, COVID-19 infection during pregnancy may not lead to unfavorable maternal and neonatal outcomes. |
topic |
SARS-CoV-2 COVID-19 Pregnant women Neonates Clinical features |
url |
https://doi.org/10.1186/s12884-020-03461-2 |
work_keys_str_mv |
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