Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment
Oxidative stress, protein misfolding, protein complex formation, and detergent insolubility are biochemical features of Alzheimer’s disease (AD). We tested the cause-and-effect relationships among these using MC65 human neuroblastoma cells that exhibit toxicity upon conditional expression of carboxy...
Main Authors: | Randall L. Woltjer, Wendy McMahan, Dejan Milatovic, John D. Kjerulf, Feng-Shiun Shie, Lisa G. Rung, Kathleen S. Montine, Thomas J. Montine |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-02-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996106002609 |
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