Characterization of Sigma Factor Genes in Streptomyces lividans TK24 Using a Genomic Library-Based Approach for Multiple Gene Deletions

Characterization of Sigma Factor Genes in Streptomyces lividans TK24 Using a Genomic Library-Based Approach for Multiple Gene Deletions

Alternative sigma factors control numerous aspects of bacterial life, including adaptation to physiological stresses, morphological development, persistence states and virulence. This is especially true for the physiologically complex actinobacteria. Here we report the development of a robust gene d...

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Main Authors: Yuriy Rebets, Konstantinos C. Tsolis, Elísabet Eik Guðmundsdóttir, Joachim Koepff, Beata Wawiernia, Tobias Busche, Arne Bleidt, Liliya Horbal, Maksym Myronovskyi, Yousra Ahmed, Wolfgang Wiechert, Christian Rückert, Mohamed B. Hamed, Bohdan Bilyk, Jozef Anné, Ólafur Friðjónsson, Jörn Kalinowski, Marco Oldiges, Anastassios Economou, Andriy Luzhetskyy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Streptomyces lividans
genomic library
σ-factor
strain phenotyping
transcriptomics
secretomics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03033/full

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