Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review
Pathogenic microorganisms exploit host metabolism for sustained survival by rewiring its metabolic interactions. Therefore, several metabolic changes are induced in both pathogen and host cells in the course of infection. A systems-based approach to elucidate those changes includes the integrative u...
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doaj-e19b728d035c4216a1d6c852e4c3cce72020-11-25T02:36:51ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-02-011010.3389/fcimb.2020.00052506726Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-ReviewTunahan Çakır0Gianni Panagiotou1Reaz Uddin2Saliha Durmuş3Department of Bioengineering, Gebze Technical University, Kocaeli, TurkeyLeibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute, Jena, GermanyDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanDepartment of Bioengineering, Gebze Technical University, Kocaeli, TurkeyPathogenic microorganisms exploit host metabolism for sustained survival by rewiring its metabolic interactions. Therefore, several metabolic changes are induced in both pathogen and host cells in the course of infection. A systems-based approach to elucidate those changes includes the integrative use of genome-scale metabolic networks and molecular omics data, with the overall goal of better characterizing infection mechanisms for novel treatment strategies. This review focuses on novel aspects of metabolism-oriented systems-based investigation of pathogen-human interactions. The reviewed approaches are the generation of dual-omics data for the characterization of metabolic signatures of pathogen-host interactions, the reconstruction of pathogen-host integrated genome-scale metabolic networks, which has a high potential to be applied to pathogen-gut microbiota interactions, and the structure-based analysis of enzymes playing role in those interactions. The integrative use of those approaches will pave the way for the identification of novel biomarkers and drug targets for the prediction and prevention of infectious diseases.https://www.frontiersin.org/article/10.3389/fcimb.2020.00052/fullinfectious diseasesgenome-scale metabolic networkspathogen-host interactionstranscriptomemetabolomegut microbiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tunahan Çakır Gianni Panagiotou Reaz Uddin Saliha Durmuş |
spellingShingle |
Tunahan Çakır Gianni Panagiotou Reaz Uddin Saliha Durmuş Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review Frontiers in Cellular and Infection Microbiology infectious diseases genome-scale metabolic networks pathogen-host interactions transcriptome metabolome gut microbiota |
author_facet |
Tunahan Çakır Gianni Panagiotou Reaz Uddin Saliha Durmuş |
author_sort |
Tunahan Çakır |
title |
Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review |
title_short |
Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review |
title_full |
Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review |
title_fullStr |
Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review |
title_full_unstemmed |
Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review |
title_sort |
novel approaches for systems biology of metabolism-oriented pathogen-human interactions: a mini-review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-02-01 |
description |
Pathogenic microorganisms exploit host metabolism for sustained survival by rewiring its metabolic interactions. Therefore, several metabolic changes are induced in both pathogen and host cells in the course of infection. A systems-based approach to elucidate those changes includes the integrative use of genome-scale metabolic networks and molecular omics data, with the overall goal of better characterizing infection mechanisms for novel treatment strategies. This review focuses on novel aspects of metabolism-oriented systems-based investigation of pathogen-human interactions. The reviewed approaches are the generation of dual-omics data for the characterization of metabolic signatures of pathogen-host interactions, the reconstruction of pathogen-host integrated genome-scale metabolic networks, which has a high potential to be applied to pathogen-gut microbiota interactions, and the structure-based analysis of enzymes playing role in those interactions. The integrative use of those approaches will pave the way for the identification of novel biomarkers and drug targets for the prediction and prevention of infectious diseases. |
topic |
infectious diseases genome-scale metabolic networks pathogen-host interactions transcriptome metabolome gut microbiota |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2020.00052/full |
work_keys_str_mv |
AT tunahancakır novelapproachesforsystemsbiologyofmetabolismorientedpathogenhumaninteractionsaminireview AT giannipanagiotou novelapproachesforsystemsbiologyofmetabolismorientedpathogenhumaninteractionsaminireview AT reazuddin novelapproachesforsystemsbiologyofmetabolismorientedpathogenhumaninteractionsaminireview AT salihadurmus novelapproachesforsystemsbiologyofmetabolismorientedpathogenhumaninteractionsaminireview |
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