Tracking TCRβ sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region

Tracking TCRβ sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region

To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses during chronic infection and antiviral therapy. Co...

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Bibliographic Details
Main Authors: Mark W Robinson, Joseph eHughes, Gavin S Wilkie, Rachael eSwann, Stephen T Barclay, Peter R Mills, Arvind H Patel, Emma C Thomson, John eMcLauchlan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
Hepatitis C virus
high-throughput sequencing
Complementarity determining region 3
TRBV
TRBJ
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00131/full

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