Association of mast cells with lung function in chronic obstructive pulmonary disease
<p>Abstract</p> <p>Background</p> <p>In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation...
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doaj-e19ffb96b97c475391103f40b2491ce52020-11-25T01:55:01ZengBMCRespiratory Research1465-99212008-09-01916410.1186/1465-9921-9-64Association of mast cells with lung function in chronic obstructive pulmonary diseaseLuinge Marjan ASmith MiekeLodewijk MoniqueRutgers BeaVonk Judith MPostma Dirkje SGosman Margot MEten Hacken Nick HTTimens Wim<p>Abstract</p> <p>Background</p> <p>In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function.</p> <p>Methods</p> <p>Lung tissue sections from 19 COPD patients (median [interquartile range] FEV<sub>1</sub>% predicted 56 [23–75]) and 10 controls were stained for tryptase and chymase. Numbers of MC-T and MC-C were determined in different regions of central and peripheral airways and percentage of degranulation was determined.</p> <p>Results</p> <p>COPD patients had lower MC-T numbers in the subepithelial area of central airways than controls. In COPD, MC-T numbers in the airway wall and more specifically in the epithelium and subepithelial area of peripheral airways correlated positively with FEV<sub>1</sub>/VC (Spearman's rho (r<sub>s</sub>) 0.47, p = 0.05 and r<sub>s </sub>0.48, p = 0.05, respectively); MC-C numbers in airway smooth muscle of peripheral airways correlated positively with FEV<sub>1</sub>% predicted (r<sub>s </sub>0.57, p = 0.02). Both in COPD patients and controls the percentage of degranulated MC-T and MC-C mast cells was higher in peripheral than in central airways (all p < 0.05), but this was not different between the groups.</p> <p>Conclusion</p> <p>More MC-T and MC-C in peripheral airways correlate with better lung function in COPD patients. It is yet to determine whether this reflects a protective association of mast cells with COPD pathogenesis, or that other explanations are to be considered.</p> http://respiratory-research.com/content/9/1/64 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luinge Marjan A Smith Mieke Lodewijk Monique Rutgers Bea Vonk Judith M Postma Dirkje S Gosman Margot ME ten Hacken Nick HT Timens Wim |
spellingShingle |
Luinge Marjan A Smith Mieke Lodewijk Monique Rutgers Bea Vonk Judith M Postma Dirkje S Gosman Margot ME ten Hacken Nick HT Timens Wim Association of mast cells with lung function in chronic obstructive pulmonary disease Respiratory Research |
author_facet |
Luinge Marjan A Smith Mieke Lodewijk Monique Rutgers Bea Vonk Judith M Postma Dirkje S Gosman Margot ME ten Hacken Nick HT Timens Wim |
author_sort |
Luinge Marjan A |
title |
Association of mast cells with lung function in chronic obstructive pulmonary disease |
title_short |
Association of mast cells with lung function in chronic obstructive pulmonary disease |
title_full |
Association of mast cells with lung function in chronic obstructive pulmonary disease |
title_fullStr |
Association of mast cells with lung function in chronic obstructive pulmonary disease |
title_full_unstemmed |
Association of mast cells with lung function in chronic obstructive pulmonary disease |
title_sort |
association of mast cells with lung function in chronic obstructive pulmonary disease |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-9921 |
publishDate |
2008-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function.</p> <p>Methods</p> <p>Lung tissue sections from 19 COPD patients (median [interquartile range] FEV<sub>1</sub>% predicted 56 [23–75]) and 10 controls were stained for tryptase and chymase. Numbers of MC-T and MC-C were determined in different regions of central and peripheral airways and percentage of degranulation was determined.</p> <p>Results</p> <p>COPD patients had lower MC-T numbers in the subepithelial area of central airways than controls. In COPD, MC-T numbers in the airway wall and more specifically in the epithelium and subepithelial area of peripheral airways correlated positively with FEV<sub>1</sub>/VC (Spearman's rho (r<sub>s</sub>) 0.47, p = 0.05 and r<sub>s </sub>0.48, p = 0.05, respectively); MC-C numbers in airway smooth muscle of peripheral airways correlated positively with FEV<sub>1</sub>% predicted (r<sub>s </sub>0.57, p = 0.02). Both in COPD patients and controls the percentage of degranulated MC-T and MC-C mast cells was higher in peripheral than in central airways (all p < 0.05), but this was not different between the groups.</p> <p>Conclusion</p> <p>More MC-T and MC-C in peripheral airways correlate with better lung function in COPD patients. It is yet to determine whether this reflects a protective association of mast cells with COPD pathogenesis, or that other explanations are to be considered.</p> |
url |
http://respiratory-research.com/content/9/1/64 |
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