The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

• Main Authors: Kang In Choe, Joo Hee Kwon, Kwan Hee Park, Myeong Hwan Oh, Manh Heun Kim, Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha, Min Won Lee
• Format: Article
• Language: English
• Published: MDPI AG 2012-09-01
• Series: Molecules
• Subjects: Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC
• Online Access: http://www.mdpi.com/1420-3049/17/10/11484
• ISSN: 1420-3049

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.