Targets Fishing and Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluation of Clickable Activity-Based Probe

Targets Fishing and Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluation of Clickable Activity-Based Probe

Calenduloside E (CE), a natural triterpenoid compound isolated from Aralia elata, can protect against ox-LDL-induced human umbilical vein endothelial cell (HUVEC) injury in our previous reports. However, the exact targets and mechanisms of CE remain elusive. For the sake of resolving this question,...

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Bibliographic Details
Main Authors: Shan Wang, Yu Tian, Jing-Yi Zhang, Hui-Bo Xu, Ping Zhou, Min Wang, Sen-Bao Lu, Yun Luo, Gui-Bo Sun, Xu-Dong Xu, Xiao-Bo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
Calenduloside E
clickable activity based protein profiling
computational chemistry
HUVECs
Hsp90AB1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00532/full

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