Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population
Objective: To evaluate the effect of paternal age on in-vitro fertilization (IVF) outcomes. Design: Retrospective cohort study. Setting: Reproductive Endocrinology and Infertility Unit. Patients: The study included 451 couples undergoing their first IVF cycle. Main outcome measures: Effect of advanc...
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doaj-e1acc2b98a4447f79cf94d069169a7d02020-11-25T02:14:18ZengSpringerOpenMiddle East Fertility Society Journal1110-56902015-09-0120320420810.1016/j.mefs.2014.06.002Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi populationSamaher Saud Alfaraj0Faisel Yunus1Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Unit, King Abdul-Aziz Medical City, P.O. Box 22490, Zip 11426 Riyadh, Saudi ArabiaDepartment of Epidemiology and Biostatistics, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaObjective: To evaluate the effect of paternal age on in-vitro fertilization (IVF) outcomes. Design: Retrospective cohort study. Setting: Reproductive Endocrinology and Infertility Unit. Patients: The study included 451 couples undergoing their first IVF cycle. Main outcome measures: Effect of advancing paternal age on: semen parameters; IVF cycle-related factors e.g., number of oocyte retrieved, fertilization rate, high quality embryo rate; and IVF outcome i.e., pregnancy rate. Results: The mean paternal age in our study was 36.3 years (range: 24–76 years). Approximately half of the study couples (51.9%) had secondary infertility with anovulation being the major cause. We found no significant correlations between the advancing paternal age and the semen parameters – sperm volume (p = 0.28), sperm concentration (p = 0.47), or sperm motility (p = 0.91). IVF cycle-related factors did not significantly differ for advancing paternal age groups – number of oocyte retrieved (p = 0.52), number of embryos fertilized (p = 0.14), fertilization rate (p = 0.94), or the high quality embryo rate (p = 0.84). Likewise, we found no significant association between the advancing paternal age and the positive IVF outcome i.e., the positive serum pregnancy test (p = 0.64). Conclusion: Advancing paternal age does not affect the IVF outcomes in a Saudi population.http://www.sciencedirect.com/science/article/pii/S1110569014000648Paternal ageMaternal ageInfertilityIVF outcomesSemen parameters |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samaher Saud Alfaraj Faisel Yunus |
spellingShingle |
Samaher Saud Alfaraj Faisel Yunus Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population Middle East Fertility Society Journal Paternal age Maternal age Infertility IVF outcomes Semen parameters |
author_facet |
Samaher Saud Alfaraj Faisel Yunus |
author_sort |
Samaher Saud Alfaraj |
title |
Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population |
title_short |
Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population |
title_full |
Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population |
title_fullStr |
Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population |
title_full_unstemmed |
Advancing paternal age does not affect in-vitro fertilization (IVF) outcomes in a Saudi population |
title_sort |
advancing paternal age does not affect in-vitro fertilization (ivf) outcomes in a saudi population |
publisher |
SpringerOpen |
series |
Middle East Fertility Society Journal |
issn |
1110-5690 |
publishDate |
2015-09-01 |
description |
Objective: To evaluate the effect of paternal age on in-vitro fertilization (IVF) outcomes.
Design: Retrospective cohort study.
Setting: Reproductive Endocrinology and Infertility Unit.
Patients: The study included 451 couples undergoing their first IVF cycle.
Main outcome measures: Effect of advancing paternal age on: semen parameters; IVF cycle-related factors e.g., number of oocyte retrieved, fertilization rate, high quality embryo rate; and IVF outcome i.e., pregnancy rate.
Results: The mean paternal age in our study was 36.3 years (range: 24–76 years). Approximately half of the study couples (51.9%) had secondary infertility with anovulation being the major cause. We found no significant correlations between the advancing paternal age and the semen parameters – sperm volume (p = 0.28), sperm concentration (p = 0.47), or sperm motility (p = 0.91). IVF cycle-related factors did not significantly differ for advancing paternal age groups – number of oocyte retrieved (p = 0.52), number of embryos fertilized (p = 0.14), fertilization rate (p = 0.94), or the high quality embryo rate (p = 0.84). Likewise, we found no significant association between the advancing paternal age and the positive IVF outcome i.e., the positive serum pregnancy test (p = 0.64).
Conclusion: Advancing paternal age does not affect the IVF outcomes in a Saudi population. |
topic |
Paternal age Maternal age Infertility IVF outcomes Semen parameters |
url |
http://www.sciencedirect.com/science/article/pii/S1110569014000648 |
work_keys_str_mv |
AT samahersaudalfaraj advancingpaternalagedoesnotaffectinvitrofertilizationivfoutcomesinasaudipopulation AT faiselyunus advancingpaternalagedoesnotaffectinvitrofertilizationivfoutcomesinasaudipopulation |
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