Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity

Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity

Abstract Background Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway...

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Bibliographic Details
Main Authors: Lifeng Li, Li Yang, Shiqi Cheng, Zhirui Fan, Zhibo Shen, Wenhua Xue, Yujia Zheng, Feng Li, Dong Wang, Kai Zhang, Jingyao Lian, Dan Wang, Zijia Zhu, Jie Zhao, Yi Zhang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Cancer
Subjects:
GBE1
STING pathway
Type I interferon
T cell infiltration
PD-L1
Anti-tumor immunity
Online Access:http://link.springer.com/article/10.1186/s12943-019-1027-x

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